New hope for the joyless: pill aims to restore pleasure in Tough-to-Treat depression

NCT ID NCT05550532

Summary

This study tested whether adding a new drug called aticaprant to a person's current antidepressant could help improve symptoms in adults with major depression who also experience a severe loss of pleasure (anhedonia) and haven't gotten enough relief from their current medication. About 444 participants were randomly assigned to receive either aticaprant or a placebo pill for 43 days, in addition to their regular antidepressant. The main goal was to see if aticaprant was better than the placebo at reducing overall depression scores and specifically improving the ability to feel pleasure.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ANHEDONIA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • APG Research LLC

    Orlando, Florida, 32803, United States

  • Alpha Recherche Clinique

    Québec, Quebec, G2J 0C4, Canada

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Associacao Hospitalar Moinhos de Vento

    Porto Alegre, 90035-001, Brazil

  • Beijing Anding Hospital of Capital Medical University

    Beijing, 100088, China

  • Beijing Huilongguan Hospital

    Beijing, 100096, China

  • Bravo Health Care Center

    North Bay Village, Florida, 33141, United States

  • Bucheon St. Mary's Hospital

    Bucheon-si, 14647, South Korea

  • C I A P Centro de investigacion y Asistencia en Psiquiatria

    Rosario, 2000, Argentina

  • CBH Health

    Gaithersburg, Maryland, 20877, United States

  • CDC Research Institute LLC

    Port Saint Lucie, Florida, 34952, United States

  • CEN Consultorios Especializados en Neurociencias

    Córdoba, 5000FJF, Argentina

  • CHA University ilsan Medical Center

    Goyang, 10414, South Korea

  • CHRU de Tours Clinique Psychiatrique Universitaire

    Tours, 37044, France

  • CHU Clermont-Ferrand - Hopital Gabriel Montpied

    Clermont-Ferrand, 63000, France

  • CHU de Brest - Hopital de la Cavale Blanche

    Bohars, 29820, France

  • CHU de Nantes hotel Dieu

    Nantes, 44093, France

  • CMB Clinical Trials

    Santee, California, 92071, United States

  • CNS Clinical Research Group

    Coral Springs, Florida, 33067, United States

  • Cabinet Medical des Drs Prizac-Desbonnet Scottez

    Douai, 59500, France

  • California Neuroscience Research

    Sherman Oaks, California, 91403, United States

  • Cape Town Clinical Research Centre

    Cape Town, 7530, South Africa

  • Cedar Psychiatry

    Murray, Utah, 84107, United States

  • Centro Medico Luquez

    Córdoba, X5006IKK, Argentina

  • Centrum Medyczne Care Clinic Katowice

    Katowice, 40568, Poland

  • Cheng Hsin General Hospital

    Taipei, 112, Taiwan

  • China Medical University Hospital

    Taichung, 40447, Taiwan

  • Clinica El Jardin

    Santiago del Estero, 4200, Argentina

  • Clinica Mayo de UMCB

    San Miguel de Tucumán, 4000, Argentina

  • Clinica Privada de Salud Mental Santa Teresa de Ávila

    La Plata, Thanks, Argentina

  • Clinical Trials of South Carolina

    Charleston, South Carolina, 29406, United States

  • Clinsante Osrodek Badan Klinicznych

    Bydgoszcz, 85 794, Poland

  • Combined Research Orlando

    Orlando, Florida, 32803, United States

  • Conrad Clinical Research

    Edmond, Oklahoma, 73013, United States

  • Core Clinical Research

    Everett, Washington, 98201, United States

  • Crisis Resolution and Home Treatment Team

    Wigan and Leigh, WN7 1YN, United Kingdom

  • Crystal Comfort s.r.o.

    Vranov nad Topľou, 9301, Slovakia

  • DCC 'Sv. Vrach and Sv. Sv. Kuzma and Damyan', OOD

    Sofia, 1408, Bulgaria

  • DIEX Recherche Sherbrooke Inc

    Sherbrooke, Quebec, J1L 0H8, Canada

  • Diagnostic Consulting Center Mladost - M Varna

    Varna, 9020, Bulgaria

  • Donald J Garcia Jr MD PA

    Austin, Texas, 78737, United States

  • Epamed sro

    Košice, 040 11, Slovakia

  • Erie County Medical Center

    Buffalo, New York, 14215, United States

  • Ezy Medical Research

    Miami, Florida, 33175, United States

  • Felicidad Medical Research

    Miami, Florida, 33184, United States

  • Filip Rybakowski Specjalistyczna Praktyka Lekarska

    Poznan, 60-744, Poland

  • Florida Research Center Inc.

    Miami, Florida, 33174, United States

  • Fundacion para el Estudio y Tratamiento de las Enfermedades Mentales

    Buenos Aires, C1133AAH, Argentina

  • Gert Bosch Pretoria South Africa

    Pretoria, 181, South Africa

  • Global Medical Institutes

    Miami, Florida, 33125, United States

  • Global Medical Institutes

    Moosic, Pennsylvania, 18507, United States

  • Guangdong Provincial People's Hospital

    Guangzhou, 510060, China

  • Hebei Mental Health Center

    Baoding, 071000, China

  • Hopital Sainte Anne

    Paris, 75674, France

  • Huzhou third people's Hospital

    Huzhou, 313000, China

  • INSA Instituto de Neurociencias San Agustín

    La Plata, 1900, Argentina

  • Indywidualna Specjalistyczna Praktyka Lekarska Agnieszka Remlinger Molenda

    Suchy Las, 62-002, Poland

  • Inje University Haeundae Paik Hospital

    Busan, 48108, South Korea

  • Institut Neuropsychiatricke pece

    Prague, 186 00, Czechia

  • Institute of Psychiatry

    London, SE5 8AF, United Kingdom

  • Instituto Medico DAMIC

    Córdoba, X5003DCE, Argentina

  • K2 Medical Research

    Maitland, Florida, 32751, United States

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Korea University Ansan Hospital

    Gyeonggi-do, 15355, South Korea

  • KyungHee University Hospital

    Seoul, 02447, South Korea

  • LCC Medical Research Institute Inc

    Miami, Florida, 33126, United States

  • Lehigh Center for Clinical Research LLC

    Allentown, Pennsylvania, 18103, United States

  • Liptovska Nemocnica S Poliklinikou Mudr. Ivana Stodolu

    Liptovský Mikuláš, 03123, Slovakia

  • MCB Clinical Research Centers LLC

    Colorado Springs, Colorado, 80910, United States

  • MHC - Sofia, EOOD

    Sofia, 1202, Bulgaria

  • Manhattan Behavioral Medicine

    New York, New York, 10036, United States

  • Medical Center Hera EOOD

    Sofia, 1510, Bulgaria

  • Medical Center Intermedica, OOD

    Sofia, 1680, Bulgaria

  • Medical Services Prague S R O

    Prague, 16000, Czechia

  • Michigan Clinical Research Institute

    Ann Arbor, Michigan, 48105, United States

  • Midwest Research Group

    Saint Charles, Missouri, 63304, United States

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112, United States

  • Moorgreen Hospital

    Southampton, SO30 3JB, United Kingdom

  • Nemocnica s poliklinikou Prievidza so sidlom v Bojniciach

    Bojnice, 97201, Slovakia

  • Neuroterapie KH S R O

    Kutná Hora, 284 01, Czechia

  • New Hope Clinical Research

    Charlotte, North Carolina, 28211, United States

  • New Life Medical Research Center, Inc.

    Hialeah, Florida, 33012, United States

  • Next Level Clinical Trials, LLC

    West Covina, California, 91790, United States

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Pacific Clinical Research Medical Group

    Upland, California, 91786, United States

  • Pacific Neuropsychiatric Specialists

    Orange, California, 92868, United States

  • Paradigm Research Professionals, LLC

    Oklahoma City, Oklahoma, 73118, United States

  • Peking University Sixth Hospital

    Beijing, 100191, China

  • Premier Psychiatric Research Institute, LLC

    Lincoln, Nebraska, 68526, United States

  • Prospective Research Innovations Inc

    Rancho Cucamonga, California, 91730, United States

  • Psychiatric Medicine Associates

    Skokie, Illinois, 60076, United States

  • Psychiatricka Ambulancia Mentum S.R.O.

    Bratislava, 82007, Slovakia

  • Psychiatricka Ambulancia Psycholine S.R.O.

    Rimavská Sobota, 97901, Slovakia

  • Psychiatricka ambulance, MUDr. Marta Holanova

    Brno, 61500, Czechia

  • Psychomed-Svatosavsky, s.r.o.

    Banská Bystrica, 97401, Slovakia

  • Quantum Laboratories

    Pompano Beach, Florida, 33064, United States

  • R and H Clinical Research

    Stafford, Texas, 77477, United States

  • Relaro Medical Trials

    Dallas, Texas, 75243, United States

  • Renfrewshire CMHT

    Paisley, PA1 1JS, United Kingdom

  • Revive Research Institute

    Farmington Hills, Michigan, 48334, United States

  • Royal Edinburgh Hospital

    Edinburgh, EH10 5HF, United Kingdom

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sarkis Clinical Trials

    Gainesville, Florida, 32607, United States

  • Seoul National University Hospital

    Seoul, 3080, South Korea

  • Shanghai Mental Health Center

    Shanghai, 200030, China

  • Somerset West Clinical Research Unit

    Strand, 7140, South Africa

  • Sooner Clinical Research

    Oklahoma City, Oklahoma, 73112, United States

  • Sunwise Clinical Research

    Lafayette, California, 94549, United States

  • Suzhou Guangji Hospital

    Suzhou, 215003, China

  • Taipei Medical University

    Taipei, 110, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Tandem Clinical Research

    Marrero, Louisiana, 70072, United States

  • The Catholic University of Korea Yeouido St. Mary's Hospital

    Seoul, 07345, South Korea

  • The Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, 450052, China

  • The First Hospital of Hebei Medical University

    Shijiazhuang, 050031, China

  • The second Xiangya Hospital of Central South University

    Changsha, 410011, China

  • Tianjin Anding Hospital

    Tianjin, 300222, China

  • Tongji Hospital of Tongji University

    Shanghai, 200065, China

  • Trial Tech Tecnologia em Pesquisas com Medicamentos

    Curitiba, 80240-280, Brazil

  • UT Southwestern Medical Center

    Dallas, Texas, 75247-9119, United States

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35205, United States

  • University of California San Diego Medical Center

    San Diego, California, 92103, United States

  • University of Sussex

    Brighton, BN1 9RY, United Kingdom

  • Univerzitna nemocnica L. Pasteura Kosice

    Košice, 04190, Slovakia

  • Vital Care Research

    Miami, Florida, 33122, United States

  • West China Hospital Sichuan University

    Chengdu, 610041, China

  • Wexner Medical Center at the Ohio State University

    Columbus, Ohio, 43221, United States

  • Wuhan Mental Health Center

    Wuhan, 430000, China

  • Wuhu Hospital of Beijing Anding hospital

    Wuhu, 242407, China

  • XiAn Mental Healthcare Center

    Xi'an, 710061, China

Conditions

Explore the condition pages connected to this study.