New hope for the joyless: experimental pill targets core symptom of depression
NCT ID NCT05455684
Summary
This study tested whether adding a new daily pill called aticaprant to a person's current antidepressant could better treat major depression, specifically for people who experience a severe lack of pleasure (anhedonia). Over 500 adults who weren't getting enough benefit from their standard antidepressant participated. They were randomly assigned to receive either aticaprant or a placebo pill for 43 days to see which group improved more.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A Plus Research
Miami, Florida, 33144, United States
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A Shine S R O
Pilsen, 301 00, Czechia
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AD71 s.r.o.
Prague, 109 00, Czechia
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ASST Fatebenefratelli Sacco
Milan, 20157, Italy
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AUSL LE di Lecce
Lecce, 73100, Italy
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ActivMed Practices and Research
Methuen, Massachusetts, 01844, United States
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Advanced Research Center Inc
Anaheim, California, 92805, United States
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Albert Road Clinic
Melbourne, 3004, Australia
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Alpine Research Organization
Clinton, Utah, 84015, United States
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Ambulatory Group practice for specialized help in psychiary Philipopolis ODD
Plovdiv, 4002, Bulgaria
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Ambulatory for Individual Practice for Specialized Medical Care in Psychiatry Dr. Ivo Natsov ET
Cherven Bryag, 5980, Bulgaria
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Amedica Research Institute Inc
Hialeah, Florida, 33013, United States
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Anima
Alken, 3570, Belgium
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Asclepes Research
Long Beach, California, 90807, United States
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Azienda Ospedaliera Universitaria Senese Policlinico Santa Maria alle Scotte
Siena, 53100, Italy
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Azienda Ospedaliero Universitaria Mater Domini
Catanzaro, 88100, Italy
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Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII)
Bergamo, 24127, Italy
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BR Trials
São Paulo, 05003 020, Brazil
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Bay Area Clinical Services
Friendswood, Texas, 77546, United States
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Behavioral Research Specialists LLC
Glendale, California, 91206, United States
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Bioscience Research LLC
Mount Kisco, New York, 10549, United States
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Bugat Pal Korhaz
Gyöngyös, 3200, Hungary
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C.H.U. Brugmann
Brussels, 1020, Belgium
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CEMEC - Centro Multidisciplinar de Estudos Clínicos
São Bernardo do Campo, 09715-090, Brazil
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CENPIA
La Plata, 1902, Argentina
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CENydET - Centro Neurobiologico y de Stress Traumatico
Ciudad Autonoma Buenos Aires, 1058 AAJ, Argentina
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CIPREC
Buenos Aires, C1061AAS, Argentina
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CPQuali Pesquisa Clinica LTDA ME
São Paulo, 01228-900, Brazil
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Centrum Badan Klinicznych PI House sp z o o
Gdansk, 80 546, Poland
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Charak Center for Health and Wellness
Garfield Heights, Ohio, 44125, United States
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Chicago Research Center
Chicago, Illinois, 60634, United States
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Clinical Trial Network - Houston
Houston, Texas, 77074, United States
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Clinical Trials of America
Monroe, Louisiana, 71203, United States
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Clintrial s r o
Prague, 100 00, Czechia
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Convenient Medical Center
Hialeah, Florida, 33013, United States
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Corporacio Sanitari Parc Tauli
Sabadell, 08208, Spain
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Dr Mathe es Tarsa Bt
Kalocsa, 6300, Hungary
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Excell Research Inc
Oceanside, California, 92056, United States
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Fieve Clinical Research Inc
New York, New York, 10168, United States
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Finger Lakes Clinical Research
Rochester, New York, 14618, United States
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Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Fund. Champalimaud
Lisbon, 1400 038, Portugal
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Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
São José do Rio Preto, 15090-000, Brazil
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Fundacion Lennox
Córdoba, 5000, Argentina
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Gabinet Lekarski Psychiatryczny Ireneusz Kaczorowski
Bełchatów, 97-400, Poland
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Galiz Research
Hialeah, Florida, 33016, United States
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Gulfcoast Medical Research Center
Fort Myers, Florida, 33912, United States
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Hosp Clinic de Barcelona
Barcelona, 08036, Spain
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Hosp Regional Univ de Malaga
Málaga, 29011, Spain
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Hosp Univ Vall D Hebron
Barcelona, 08035, Spain
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Hosp. Alvaro Cunqueiro
Vigo, 36312, Spain
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Hosp. El Bierzo
Ponferrada, 24404, Spain
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Hosp. Psiquiatrico Alava
Vitoria-Gasteiz, 01006, Spain
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Hosp. Univ. La Paz
Madrid, 28046, Spain
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Hosp. Univ. Son Espases
Palma de Mallorca, 07120, Spain
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Hospital CUF Inf. Santo
Lisbon, 1350 179, Portugal
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Hospital Italiano
Buenos Aires, 1199, Argentina
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Hospital de Braga
Braga, 4710-243, Portugal
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Innovative Research of West Florida, Incorporated
Clearwater, Florida, 33756, United States
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Institucion Hosp Hestia Palau
Barcelona, 08025, Spain
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Instituto Goiano de Neuropsiquiatria
Goiânia, 74093 040, Brazil
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Instituto Medico de La Fundacion Estudios Clinicos
Rosario, S2000DEJ, Argentina
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Medical Center Mentalcare OOD
Plovdiv, 4004, Bulgaria
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Medical Center St. Naum
Sofia, 1113, Bulgaria
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Medical Research Group of Central Florida
Orange City, Florida, 32763, United States
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Mental Health Center - Rousse
Rousse, 7003, Bulgaria
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Mental Health Center - Veliko Tarnovo EOOD
Veliko Tarnovo, 5000, Bulgaria
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Meridian International Research
Miami Gardens, Florida, 33014, United States
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Midwest Clinical Research Center
Dayton, Ohio, 45417, United States
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Mlynowamed Specjalistyczny Psychiatryczny Gabinet Lekarski Joanna Lazarczyk
Bialystok, 15-404, Poland
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Montefiore Medical Center PRIME
The Bronx, New York, 10467, United States
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NPCRS Nucleo de Pesquisa Clinica do Rio Grande do Sul
Porto Alegre, 90430001, Brazil
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Narodni ustav dusevniho zdravi
Klecany, 25067, Czechia
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NeuropsychiatrieHK, s.r.o.
Prague, 160 00, Czechia
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New Life Medical Research Center, Inc.
Hialeah, Florida, 33012, United States
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North Texas Clinical Trials
Fort Worth, Texas, 76104, United States
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Northwest Clinical Research Center
Bellevue, Washington, 98007, United States
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Nyiro Gyula Korhaz
Budapest, 1135, Hungary
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Obudai Egeszsegugyi Centrum Kft
Budapest, 1036, Hungary
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Ospedale San Raffaele
Milan, Italy
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Osrodek Badan Klinicznych CROMED
Poznan, 61-360, Poland
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Patient Priority Clinical Sites LLC
Cincinnati, Ohio, 45215, United States
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Peninsula Therapeutic & Research Group
Frankston, 3199, Australia
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Pharmax Research Clinic Inc
Miami, Florida, 33126, United States
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Praglandia s r o
Prague, 15000, Czechia
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ProbarE i Lund AB
Lund, 22222, Sweden
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ProbarE i Stockholm AB
Stockholm, 113 29, Sweden
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Proscience Research Group
Culver City, California, 90230, United States
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Psychiatric Care and Research Center (PCRC)
O'Fallon, Missouri, 63368, United States
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Psychiatricka ordinace
Ústí nad Labem, 400 01, Czechia
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PsychoTech Kft
Pécs, 7633, Hungary
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Pz Duffel
Duffel, 2570, Belgium
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Research Network America
Berwyn, Illinois, 60402, United States
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Resolution
Mendoza, M5502AHV, Argentina
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Ruschel Medicina e Pesquisa Clínica Ltda
Rio de Janeiro, 22270 060, Brazil
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SPZOZ Uniwersytecki Szpi.Klin. nr 4 UM w Lodzi
Lodz, 92-215, Poland
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STAT Research S A
Buenos Aires, C1013AAB, Argentina
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SW Biomedical Research LLC
Tucson, Arizona, 85712, United States
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Sahlgrenska Universitetssjukhuset
Gothenburg, 416 85, Sweden
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Semmelweis Egyetem
Budapest, 1083, Hungary
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Specjalistyczna Indywidualna Praktyka Lekarska
Lodz, 90-009, Poland
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Specjalistyczny Gabinet Psychiatryczny Kowalkowski Gerard
Torun, 87 100, Poland
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Studieenheten Akademiskt Specialistcentrum Stockholm
Stockholm, 113 61, Sweden
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Suburban Research Associates
Media, Pennsylvania, 19063, United States
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Syrentis Clinical Research
Santa Ana, California, 92705, United States
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The Alfred Hospital
Melbourne, 3004, Australia
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Tolna Megyei Balassa Janos Korhaz
Szekszárd, 7100, Hungary
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USF, Department of Psychiatry and Behavioral Neurosciences
Tampa, Florida, 33613, United States
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Universidade Federal do Ceara Hospital Universitario Walter Cantidio
Fortaleza, 60430-370, Brazil
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University of Arizona
Tucson, Arizona, 85713, United States
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University of Cincinnati Medical Center
Cincinnati, Ohio, 45219, United States
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University of Connecticut Health Center
Farmington, Connecticut, 06030, United States
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University of Kansas Medical Center Research Institute
Kansas City, Kansas, 66160, United States
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University of Miami
Miami Lakes, Florida, 33016, United States
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University of Pennsylvania - Perelman School of Medicine
Philadelphia, Pennsylvania, 19104, United States
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University of Virginia
Charlottesville, Virginia, 22903, United States
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Vertex Research Group, Inc
Clermont, Florida, 34711, United States
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Viking Clinical Research Ltd
Temecula, California, 92591, United States
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Vitaz
Sint-Niklaas, 9100, Belgium
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West Houston Clinical Research Service
Bellaire, Texas, 77401, United States
Conditions
Explore the condition pages connected to this study.