New drug cocktail shows promise against tough head and neck cancer

NCT ID NCT04665843

Completed Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tested whether adding tiragolumab to atezolizumab (Tecentriq) helps shrink tumors better than atezolizumab alone in people with advanced head and neck cancer that has come back or spread. The study enrolled 123 adults whose tumors have a specific protein (PD-L1). Researchers measured how many patients had their tumors shrink significantly. The goal is to find a more effective first treatment for this hard-to-treat cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atezolizumab (Tecentriq) and tiragolumab
What this could lead to: If this combination works better than atezolizumab alone, it could offer a new first-line treatment option for people with advanced head and neck cancer.
What could go wrong: This is a phase 2 trial with only 123 participants, so results are preliminary. The combination may not improve outcomes significantly and could cause added side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SQUAMOUS CELL CARCINOMA OF HEAD AND NECK

Contacts and locations

Locations

Anticancer Hospital Ag Savas

Athens, 115 22, Greece
Asan Medical Center

Seoul, 05505, South Korea
Asst Degli Spedali Civili Di Brescia

Brescia, Lombardy, 25100, Italy
Attiko Hospital University of Athens

Athens, 12462, Greece
Auckland City Hospital, Cancer and Blood Research

Auckland, 1023, New Zealand
Azienda Ospedaliero-Universitaria Careggi

Florence, Tuscany, 50134, Italy
Bacs-Kiskun Megyei Korhaz, SZTE AOK Oktato Korhaza, Onkoradiologiai Kozpont

Kecskemét, 6000, Hungary
Beatson West of Scotland Cancer Centre

Glasgow, G12 0YN, United Kingdom
Beskidzkie Centrum Onkologii- Szpital Miejski

Bielsko-Biala, 43-300, Poland
CHU Bordeaux

Bordeaux, 33075, France
Centre Francois Baclesse

Caen, 14076, France
Centre Leon Berard

Lyon, 69373, France
Centrum Onkologii Ziemi Lubelskiej Im. ?W. Jana Z Dukli

Lublin, 20-090, Poland
Centrum Terapii Wspolczesnej J.M.Jasnorzewska Spolka Komandytowo-Akcyjna

Lodz, 90-242, Poland
China Medical University Hospital

Taichung, 404, Taiwan
Euromedical General Clinic of Thessaloniki

Thessaloniki, 546 45, Greece
Fakultni nemocnice Hradec Kralove

Hradec Králové, 500 05, Czechia
Fakultni nemocnice v Motole

Prague, 150 06, Czechia
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, Lombardy, 20133, Italy
Guys and St Thomas NHS Foundation Trust, Guys Hospital

London, SE1 9RT, United Kingdom
Gy?r-Moson-Sopron Vármegyei Petz Aladár Egyetemi Oktató Kórház

Gy?r, 9024, Hungary
Hospital Universitari Germans Trias i Pujol

Badalona, Barcelona, 08916, Spain
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Institut Catala d Oncologia Hospital Duran i Reynals

Barcelona, 08908, Spain
Institut Curie

Paris, 75231, France
Institut de Cancérologie de Lorraine

Vandœuvre-lès-Nancy, 54519, France
Institut régional du Cancer Montpellier

Montpellier, 34298, France
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Masarykuv onkologicky ustav

Brno, 656 53, Czechia
Moores Cancer Center at UC San Diego Health

La Jolla, California, 92093, United States
National Taiwan University Hospital

Zhongzheng Dist., 10048, Taiwan
Periph. University General Hospital of Heraklion Crete

Heraklion, 711 10, Greece
Pécsi Tudományegyetem

Pécs, 7623, Hungary
Ramathibodi Hospital

Bangkok, 10400, Thailand
Royal Marsden NHS Foundation Trust

Sutton, SM2 5PT, United Kingdom
SCRI Florida Cancer Specialists PAN

Tallahassee, Florida, 32308, United States
Samsung Medical Center

Seoul, 06351, South Korea
Seoul National University Hospital

Seoul, 03080, South Korea
Songklanagarind Hospital

Songkhla, 90110, Thailand
Taipei Veterans General Hospital

Taipei, 112201, Taiwan
Tennessee Oncology - Nashville

Nashville, Tennessee, 37203, United States
UCLA

Los Angeles, California, 90095, United States
Uniwersytecki Szpital Kliniczny w Poznaniu

Poznan, Poland
Uniwersyteckie Centrum Kliniczne

Gda?sk, 80-214, Poland
Velindre Cancer Centre

Cardiff, CF14 2TL, United Kingdom
Washington University School of Medicine

St Louis, Missouri, 63108, United States

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