New drug combo shows promise for untreated liver cancer

NCT ID NCT04487067

Completed Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed Phase 3 trial tested a combination of two drugs, atezolizumab and bevacizumab, in 152 people with advanced liver cancer that could not be surgically removed and had not been treated before. The goal was to check safety and how well the treatment works. The study was open-label and single-arm, meaning everyone got the same treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atezolizumab (Tecentriq) and bevacizumab (Avastin)
What this could lead to: If successful, this combination could become a standard first-line treatment for advanced liver cancer, helping control the disease and extend survival.
What could go wrong: This is a single-arm study without a comparison group, so results may be less definitive. Side effects like bleeding are a known risk with these drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, HEPATOCELLULAR

Contacts and locations

Locations

A.O. S. Orsola Malpighi

Bologna, Emilia-Romagna, 40138, Italy
A.O. Universitaria S. Martino Di Genova

Genoa, Liguria, 16132, Italy
A.O.U Careggi

Florence, Tuscany, 50124, Italy
A.O.U. Cagliari-P.O. Monserrato

Cagliari, Sardinia, 09100, Italy
A.O.U. Policlinico Paolo Giaccone

Palermo, Sicily, 90127, Italy
Arcispedale Santa Maria Nuova

Reggio Emilia, Emilia-Romagna, 42100, Italy
Azienda Osp Uni Seconda Università Degli Studi Di Napoli

Naples, Campania, 80131, Italy
Azienda Ospedaliera Di Rilievo Nazionale E Di Alta Specializzazione Garibaldi

Palermo, Sicily, 90127, Italy
Azienda Ospedaliera Ordine Mauriziano di Torino

Turin, Piedmont, 10128, Italy
Azienda Ospedaliera San Camillo Forlanini

Rome, Lazio, 00151, Italy
Azlenda Ospendaliero-Universitaria Pisana

Pisa, Tuscany, 56100, Italy
Clinica Oncologica-Ospedali Riuniti Ancona

Torrette, Tuscany, 60020, Italy
Fondazione IRCCS Ospedale Maggiore Policlinico

Milan, Lombardy, 20122, Italy
Fondazione Pascale

Naples, Campania, 80100, Italy
IOV - Istituto Oncologico Veneto - IRCCS

Padova, Veneto, 35128, Italy
IRCCS Ospedale Casa Sollievo Della Sofferenza

San Giovanni Rotondo, Apulia, 71013, Italy
Istituto Clinico Humanitas

Rozzano, Lombardy, 20089, Italy
Istituto Nazionale Dei Tumori

Milan, Lombardy, 20133, Italy
Ospedale del Mare

Naples, Campania, 80147, Italy
Ospedali Riuniti - Bergamo

Bergamo, Lombardy, 24128, Italy
Policlinico Universitario Agostino Gemelli

Rome, Lazio, 00168, Italy

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