New drug combo aims to shrink prostate tumors before surgery

NCT ID NCT05938270

First seen Nov 01, 2025 · Last updated May 08, 2026 · Updated 29 times

Summary

This study tests two drugs, saruparib and darolutamide, given alone or together before prostate removal surgery in men with newly diagnosed, localized prostate cancer. The goal is to see how the drugs affect tumor cells and check for side effects. About 120 men will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Research Site

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Research Site

    RECRUITING

    Providence, Rhode Island, 02903, United States

  • Research Site

    RECRUITING

    Melbourne, VIC 3000, Australia

  • Research Site

    RECRUITING

    South Brisbane, 4101, Australia

  • Research Site

    RECRUITING

    Vancouver, British Columbia, V5Z 1M9, Canada

  • Research Site

    RECRUITING

    Toronto, Ontario, M5G 2M9, Canada

  • Research Site

    RECRUITING

    Québec, Quebec, G1J 1Z4, Canada

  • Research Site

    RECRUITING

    Amsterdam, 1066CX, Netherlands

  • Research Site

    RECRUITING

    Nijmegen, 6525 GA, Netherlands

  • Research Site

    RECRUITING

    Barcelona, 08036, Spain

  • Research Site

    RECRUITING

    Barcelona, 8035, Spain

  • Research Site

    RECRUITING

    Madrid, 28041, Spain

  • Research Site

    RECRUITING

    Valencia, 46009, Spain

  • Research Site

    WITHDRAWN

    Ankara, 06100, Turkey (Türkiye)

  • Research Site

    WITHDRAWN

    Ankara, 6200, Turkey (Türkiye)

  • Research Site

    WITHDRAWN

    Istanbul, 34010, Turkey (Türkiye)

  • Research Site

    RECRUITING

    Cambridge, CB2 0QQ, United Kingdom

  • Research Site

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • Research Site

    RECRUITING

    Newcastle upon Tyne, NE7 7AF, United Kingdom

Conditions

Explore the condition pages connected to this study.