Could an HIV drug tame MS by targeting a common virus?

NCT ID NCT05957913

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 23 times

Summary

This study tests whether Truvada, an antiviral drug used for HIV, can reduce levels of Epstein-Barr virus (EBV) in people with multiple sclerosis (MS). EBV is linked to MS, and lowering it might help control the disease. About 50 adults with MS who have evidence of past EBV infection will take Truvada or a placebo for 12 weeks. Researchers will measure virus levels in saliva and blood, check for side effects, and track fatigue.

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Contacts and locations

Locations

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

Conditions

Explore the condition pages connected to this study.