New cell therapy shows promise in battle against Hard-to-Treat multiple myeloma

NCT ID NCT06413498

Ongoing Disease control Sponsor: Kite, A Gilead Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 4 times

Summary

This study tests a new treatment called anitocabtagene autoleucel (a type of cell therapy) against standard treatments for people with multiple myeloma that has returned or not responded to 1-3 prior therapies. About 450 participants will be randomly assigned to receive either the new cell therapy or standard care. The main goal is to see which approach better delays cancer progression and reduces signs of the disease in the bone marrow.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

AOU Città della Salute e della Scienza Presidio Ospedaliero Molinette

Torino, 10126, Italy
Amsterdam UMC - Location vUmc

Amsterdam, 1081 HV, Netherlands
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Baptist Cancer Center

Memphis, Tennessee, 38104, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
CHU De Montpellier - Hopital Saint Eloi

Montpellier, 34080, France
CHU de Lille- Hopital Claude Huriez

Lille, 59037, France
CHU de Rennes

Rennes, 59037, France
CHU de Toulouse. IUCT Oncopole

Toulouse, 31100, France
Centre Hospitalier Universitaire de Nantes

Nantes, 44093, France
Centre Hospitalier Universitaire de Poitiers

Poitiers, 86021, France
Charité - Universitätsmedizin Berlin

Berlin, 12203, Germany
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)

Duarte, California, 91010, United States
Clinica Universidad de Navarra

Pamplona, 31008, Spain
Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Complejo Asistencial Universitario de Salamanca

Salamanca, 37007, Spain
Corewell Health - Lemmen-Holton Cancer Pavilion

Grand Rapids, Michigan, 49503, United States
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States
Epworth HealthCare

Richmond, Victoria, 3121, Australia
Erasmus Medical Center

Rotterdam, 3015GD, Netherlands
Fakultni Nemocnice Ostrava

Severomoravsky KRAJ, 708 52, Czechia
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, MI, 20133, Italy
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Henry-Joyce Cancer Clinic

Nashville, Tennessee, 37232, United States
Hopital Saint Antoine

Paris, 75571, France
Hopital Saint Louis

Paris, 75010, France
Hospital Clinico Universitario Virgen de la Arrixaca

El Palmar, 30120, Spain
Hospital Clínic de Barcelona

Barcelona, 08036, Spain
Hospital Duran i Reynals

Barcelona, 08908, Spain
Hospital Universitari i Politecnic La Fe de Valencia

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Marqués de Valdecilla

Santander, 39008, Spain
Hospital Universitario Ramon Y Cajal

Madrid, 28034, Spain
Hospital Universitario Virgen del Rocio

Seville, 41013, Spain
Houston Methodist Hospital Cancer Center

Houston, Texas, 77030, United States
Huntsman Cancer Institute, University of Utah

Salt Lake City, Utah, 84112, United States
Hyogo Medical University Hospital

Hyōgo, 663-8501, Japan
Hôpital Lyon Sud

Pierre-Bénite, 69495, France
ICO Badalona-H.U. Germans Trias i Pujol

Badalona, 08916, Spain
IRCCS AOU di Bologna

Bologna, 40138, Italy
IU Melvin and Bren Simon Comprehensive Cancer Center

Indianapolis, Indiana, 46202, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Inselspital - Universitätsspital Bern

Bern, 3010, Switzerland
Institut Paoli Calmettes

Marseille, 13273, France
Instytut Hematologii i Transfuzjologii

Warsaw, 02-776, Poland
Japanese Red Cross Medical Center

Tokyo, 150-8935, Japan
Jichi Medical University Hospital

Tochigi, 329-0498, Japan
Juntendo University School of Medicine Juntendo Clinic

Tokyo, 113-8431, Japan
King's College Hospital

London, SE5 9NU, United Kingdom
LDS Hospital

Salt Lake City, Utah, 84143, United States
Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

New York, New York, 10016, United States
Leeds Teaching Hospitals NHS Trust, St James's University Hospital

Leeds, LS9 7TF, United Kingdom
Levine Cancer Institute

Charlotte, North Carolina, 28204, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Jacksonville, Florida, 32256, United States
Mayo Clinic

Rochester, Minnesota, 55902, United States
Mayo Clinic Hospital

Gilbert, Arizona, 85234, United States
McGill University Health Center

Montreal, H4A 3J1, Canada
Medical University of Vienna

Vienna, 1090, Austria
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Nagoya City University Hospital

Nagoya, 467-8602, Japan
New Mexico Cancer Research Alliance

Albuquerque, New Mexico, 87102, United States
Newcastle Hospitals NHS Foundation Trust, Freeman Hospital

Newcastle, NE7 7DN, United Kingdom
Norton Cancer Institute, St. Matthews Campus

Louisville, Kentucky, 40207, United States
Novant Health Cancer Institute Hematology- Forsyth

Winston-Salem, North Carolina, 27103, United States
Ochsner Clinical Foundation

New Orleans, Louisiana, 70121, United States
Oncology Hematology West, PC dba Nebraska Cancer Specialists - Legacy

Omaha, Nebraska, 68130, United States
Ordensklinikum Linz GmbH Elisabethinen, Hamatologie mit Stammzelltransplantation, Hamostaseologie und medizinische Onkologie

Linz, Austria
Oregon Health and Science University

Portland, Oregon, 97239, United States
Ospedale San Raffaele

Milan, 3302, Italy
Paracelsus Medizinischen Privatuniversitaet

Salzburg, A-5020, Austria
Policlinico Universitario Argostino Gemelli

Roma, 00168, Italy
QEII Health Sciences Centre

Halifax, B3H 2Y9, Canada
Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia
Royal North Shore Hospital

St Leonards, New South Wales, 2065, Australia
Royal Prince Alfred Hospital

Camperdown, New South Wales, NSW 2050, Australia
Sir Charles Gairdner Hospital

Nedlands, Western Australia, 6009, Australia
Southeastern Regional Medical Center, Inc. dba City of Hope Atlanta

Newnan, Georgia, 30265, United States
St. David's South Austin Medical Center

Austin, Texas, 78704, United States
St. Luke's Cancer Institute

Boise, Idaho, 83712, United States
Stanford Cancer Institute

Stanford, California, 94305, United States
Swedish Cancer Institute

Seattle, Washington, 98104, United States
Sylvester Comprehensive Cancer Center

Coral Gables, Florida, 33146, United States
TUM Klinikum, Rechts der Isar, Klinik und Poliklinik fur Innere Medizin III, Hamatologie und Onkologie

München, 80333, Germany
Tennessee Oncology, PLLC - Greco-Hainsworth Centers for Research

Nashville, Tennessee, 37203, United States
The Ottawa Hospital - General Campus

Ottawa, K1H 8L6, Canada
The University of Osaka Hospital

Osaka, 565-0871, Japan
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
UC San Diego Moores Cancer Center

San Diego, California, 92037, United States
UCLA Hematology/Oncology (Bowyer Infusion Clinic)

Santa Monica, California, 90404, United States
USC/Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
UZ Gent

Gent Oost-Vlaanderen, 9000, Belgium
UZ Leuven

Flemish Brabant, 3000, Belgium
Universitatsklinikum Hamburg Eppendorf

Hamburg, 20246, Germany
Universitatsklinikum Koln, Klinik I fOr lnnere Medizin

Cologne, Germany
Universitatsklinikum Leipzig

Leipzig, 4103, Germany
Universitatsklinikum Wurzburg

Tübingen, 72076, Germany
University College London Hospital

London, WC1E 6JN, United Kingdom
University Health Network - The Princess Margaret Cancer Centre

Toronto, M5G 2M9, Canada
University Hospital St. Poelten, Department of Internal Medicine I

Sankt Pölten, 3100, Austria
University Hospital of Antwerp

Edegem, Belgium
University Hospital of Wales

Cardiff, CF14 4XW, United Kingdom
University Hospitals Bristol NHS Foundation Trust, Bristol Haematology and Oncology Centre

Bristol, BS2 8ED, United Kingdom
University Medical Center Groningen

Groningen, 9700 RB, Netherlands
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Cincinnati Cancer Center

Cincinnati, Ohio, 45219, United States
University of Illinois Hospital and Health Sciences System

Chicago, Illinois, 60612, United States
University of Maryland Greenebaum Comprehensive Cancer Center

Baltimore, Maryland, 21201, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Tennessee Medical Center

Knoxville, Tennessee, 37920, United States
Universitätsklinikum Essen

Essen, Germany
Universitätsklinikum Freiburg

Freiburg im Breisgau, 79106, Germany
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu

Wroclaw, 50-367, Poland
Warszawa-Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego

Warsaw, 02-097, Poland
Weill Cornell Medicine - New York Presbyterian Hosptial

New York, New York, 10021, United States
Winship Cancer Institute, Emory University

Atlanta, Georgia, 30322, United States

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