New drug cocktail aims to fight head and neck cancer

NCT ID NCT06385080

Recruiting now Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study tests a drug called amivantamab, either alone or combined with other cancer drugs (pembrolizumab, paclitaxel, carboplatin), in people with head and neck cancer that has spread or come back. The goal is to see if these treatments are safe and can shrink tumors. About 287 participants will take part, and the study also looks at using amivantamab with pembrolizumab before and after surgery for certain patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Amivantamab (a biologic drug) given alone or with pembrolizumab, paclitaxel, or carboplatin
What this could lead to: If successful, this could point toward new treatment options for people with head and neck cancer that has spread or come back.
What could go wrong: This is an early-phase trial (phase 1b/2) with a small number of participants, so results may not apply to everyone. Side effects from the drug combinations could be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SQUAMOUS CELL CARCINOMA OF HEAD AND NECK

Contacts and locations

Locations

Addenbrooke's Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Aichi Cancer Center
RECRUITING

Nagoya, 464-8681, Japan
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Beijing Cancer Hospital of Peking University
COMPLETED

Beijing, 100142, China
CHU Nantes
RECRUITING

Nantes, 44000, France
Centre Oscar Lambret
RECRUITING

Lille, 59000, France
Centrum Onkologii Instytut im M Sklodowskiej Curie Oddzial w Gliwicach
RECRUITING

Gliwice, 44-102, Poland
Changhua Christian Hospital
RECRUITING

Changhua, 500, Taiwan
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02115, United States
Fudan Cancer Hospital
RECRUITING

Shanghai, 200032, China
Gustave Roussy
RECRUITING

Villejuif, 94805, France
Hosp Univ Vall D Hebron
RECRUITING

Barcelona, 08035, Spain
Hosp. Univ. 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hosp. Univ. Ramon Y Cajal
RECRUITING

Madrid, 28034, Spain
Imperial College London and Imperial College Healthcare NHS Trust
RECRUITING

London, W12 0HS, United Kingdom
Inst. Cat. Doncologia-H Duran I Reynals
RECRUITING

Barcelona, 08908, Spain
Institut Curie
RECRUITING

Paris, 75248, France
Institut Sainte Catherine
RECRUITING

Avignon, 84918, France
Kaohsiung Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, 833, Taiwan
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201 2013, United States
Klinikum der Landeshauptstadt Stuttgart
RECRUITING

Stuttgart, 70174, Germany
Linkou Chang Gung Memorial Hospital
RECRUITING

Taoyuan, 33382, Taiwan
Linyi Cancer Hospital
COMPLETED

Linyi, 276002, China
Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy
RECRUITING

Warsaw, 02 781, Poland
National Taiwan University Hospital
RECRUITING

Taipei, 100, Taiwan
Pantai Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, 59100, Malaysia
Royal Marsden Hospital
RECRUITING

London, SW3 6JJ, United Kingdom
Royal Marsden Hospital (Sutton)
RECRUITING

London, SM2 5PT, United Kingdom
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shanghai East Hospital
RECRUITING

Shanghai, 200120, China
Taipei Veterans General Hospital
RECRUITING

Taipei, 112, Taiwan
The Christie Nhs Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
The Royal Surrey County Hospital NHS Foundation Trust
RECRUITING

Guildford, GU2 7XX, United Kingdom
The University of Chicago Medical Center (UCMC)
RECRUITING

Chicago, Illinois, 60637, United States
Tokyo Medical University Hospital
RECRUITING

Tokyo, 160-0023, Japan
Union Hospital Tongji Medical College of Huazhong University of Science and Technology
RECRUITING

Wuhan, 430022, China
Universitaetsklinikum Essen
RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Leipzig
COMPLETED

Leipzig, 04103, Germany
University College London Hospitals
RECRUITING

London, W1T 7HA, United Kingdom
University Malaya Medical Centre
RECRUITING

Kuala Lumpur, 59100, Malaysia
University of California at San Diego Moores Cancer Center
COMPLETED

La Jolla, California, 92093, United States
University of Colorado Denver Anschultz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Maryland School of Medicine
RECRUITING

Baltimore, Maryland, 21201, United States
University of Michigan Rogel Cancer Center
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Utah Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80 214, Poland
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Washington University School Of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
West China School of Medicine/West China Hospital, Sichuan University
RECRUITING

Cheng Du Shi, 610041, China
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06520, United States

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