New hope for kids with brittle bones: experimental drug faces off against standard care
NCT ID NCT06079372
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares a new medicine, ALXN1850, to the current standard treatment (asfotase alfa) in 43 children aged 2 to 12 with hypophosphatasia, a rare genetic condition that weakens bones. All children have been on the standard treatment for at least 6 months before joining. The main goal is to see if the new drug is safe and tolerable. Researchers will also check bone healing, rickets severity, and walking ability.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Research Site
Hartford, Connecticut, 06106, United States
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Baltimore, Maryland, 21287, United States
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Minneapolis, Minnesota, 55455, United States
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Kansas City, Missouri, 64108, United States
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Durham, North Carolina, 27705, United States
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Nashville, Tennessee, 37212, United States
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Mar del Plata, B7600, Argentina
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South Brisbane, 4101, Australia
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Ottawa, Ontario, K1H 8L1, Canada
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Bunkyō City, 113-8431, Japan
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Minatoku, 105-8471, Japan
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Suita-shi, 565-0871, Japan
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Yonago-shi, 683-8504, Japan
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Altındağ, 06230, Turkey (Türkiye)
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Ankara, 06560, Turkey (Türkiye)
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Edirne, 22030, Turkey (Türkiye)
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Erzurum, 25240, Turkey (Türkiye)
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Istanbul, 34899, Turkey (Türkiye)
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Birmingham, B4 6NH, United Kingdom
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Manchester, United Kingdom
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Research Site
Sheffield, S10 2TH, United Kingdom