Could your body fight back against this rare disease drug?

NCT ID NCT05234567

Recruiting now Knowledge-focused Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 30 people with hypophosphatasia (HPP) who are taking the drug asfotase alfa. Researchers want to see if the immune system can make the drug less effective or cause serious allergic reactions. Participants will be monitored for at least 5 years to track these risks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: asfotase alfa (Strensiq)
What this could lead to: If successful, this study could help doctors understand when and why the drug stops working, leading to better monitoring or alternative treatments for hypophosphatasia.
What could go wrong: This is a small observational study, not a treatment trial. It only watches what happens and cannot prove whether the drug works or not. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hypophosphatasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOPHOSPHATASIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Clinical Trial Site
RECRUITING

Hartford, Connecticut, 06106, United States
Clinical Trial Site
RECRUITING

Chicago, Illinois, 60611, United States
Clinical Trial Site
RECRUITING

Boston, Massachusetts, 02122, United States
Clinical Trial Site
RECRUITING

Kansas City, Missouri, 64108, United States
Clinical Trial Site
RECRUITING

Mineola, New York, 11501, United States
Clinical Trial Site
NOT_YET_RECRUITING

Cincinnati, Ohio, 45229, United States
Clinical Trial Site
RECRUITING

Columbus, Ohio, 43203, United States
Clinical Trial Site
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Clinical Trial Site
RECRUITING

Nashville, Tennessee, 37112, United States
Clinical Trial Site
RECRUITING

Salt Lake City, Utah, 84108, United States
Clinical Trial Site
RECRUITING

Charlottesville, Virginia, 22903, United States
Clinical Trial Site
RECRUITING

Madison, Wisconsin, 53792, United States

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