New hope for rare bone disease: experimental drug aims to help patients walk better

NCT ID NCT06079281

Ongoing Disease control Sponsor: Alexion Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests an experimental drug called ALXN1850 in 124 adolescents and adults with hypophosphatasia, a rare genetic bone disease. Participants receive either the drug or a placebo by injection under the skin. The main goal is to see if the drug improves walking distance in 6 minutes, with other measures like sit-to-stand ability and pain. The study is active but no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ALXN1850 (recombinant alkaline phosphatase)

What this could lead to

If successful, this could provide a new treatment option for hypophosphatasia, improving mobility and reducing pain for people who have not used other therapies.

What could go wrong

This is a phase 3 trial, but results are not yet available. The drug may not work better than placebo, and side effects from the injection or the drug itself are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hypophosphatasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOPHOSPHATASIA

Contacts and locations

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Locations

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Indianapolis, Indiana, 46202, United States
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Garden City, New York, 11530, United States
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Durham, North Carolina, 27705, United States
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Columbus, Ohio, 43203, United States
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Nashville, Tennessee, 37212, United States
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Ciudad de Buenos Aires, C1199, Argentina
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Clayton, 3168, Australia
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Herston, 4029, Australia
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Parkville, 3052, Australia
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St Leonards, 2065, Australia
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Belo Horizonte, 30130-100, Brazil
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Brasília, 71625-009, Brazil
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Recife, 50740-465, Brazil
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Salvador, 40050-410, Brazil
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São Paulo, 01409-902, Brazil
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São Paulo, 05403-900, Brazil
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Calgary, Alberta, T2E 7H7, Canada
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Edmonton, Alberta, T6G 2R7, Canada
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Winnepeg, Manitoba, R3E 3P4, Canada
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Oakville, Ontario, L6M 1M1, Canada
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Trois-Rivières, Quebec, G9A 4P3, Canada
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Beijing, 100039, China
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Beijing, 100730, China
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Changsha, 430033, China
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Chengdu, 610041, China
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Nanchang, 330006, China
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Qingdao, 266035, China
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Shanghai, 201306, China
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Shenzhen, 518053, China
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Paris, 75014, France
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Poitiers, 86000, France
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Bad Reichenhall, 83435, Germany
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Berlin, 10117, Germany
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Bonn, 53127, Germany
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Hamburg, 20251, Germany
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Würzburg, 97074, Germany
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Ashkelon, 7830604, Israel
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Ramat Gan, 52621, Israel
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Florence, 50139, Italy
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Milan, 20122, Italy
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Milan, 20132, Italy
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Padova, 35128, Italy
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Pisa, 56126, Italy
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San Giovanni Rotondo, 71013, Italy
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Verona, 37134, Italy
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Hiroshima, 734-8551, Japan
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Iizuka-shi, 820-8505, Japan
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Osaka, 545-8586, Japan
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Sapporo, 060-8648, Japan
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Yaizu-shi, 425-8505, Japan
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Lodz, 93-338, Poland
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Seoul, 03722, South Korea
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Seoul, 07061, South Korea
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Suwon, 16499, South Korea
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Barcelona, 08003, Spain
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Granada, 18016, Spain
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Madrid, 28046, Spain
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San Cristóbal de La Laguna, 38320, Spain
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Santander, 39008, Spain
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Vitoria-Gasteiz, 01009, Spain
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Taipei, 100, Taiwan
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Taoyuan, 333, Taiwan
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Ankara, 06560, Turkey (Türkiye)
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Yakutiye, 25040, Turkey (Türkiye)
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London, SW170QT, United Kingdom