Immune-Boosting drug trial offers new hope to slow devastating ALS

NCT ID NCT03039673

Summary

This study tested whether a low-dose immune drug (IL-2) could slow the progression of ALS by boosting helpful immune cells that may calm inflammation in the nervous system. It involved 304 newly diagnosed ALS patients who received either the drug or a placebo for 18 months. The main goal was to see if this approach could improve survival and slow functional decline.

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Contacts and locations

Locations

  • APHM - Hôpital de la Timone

    Marseille, 13385, France

  • APHP - Groupe Hospitalier Pitié-Salpetrière

    Paris, 75651, France

  • CENTRE HOSPITALIER DE SAINT BRIEUC - Hôpital Yves Le Foll

    Saint-Brieuc, 22027, France

  • CHRU de Lille - Hôpital Roger Salengro

    Lille, 59037, France

  • CHRU de Montpellier - Hôpital Gui de Chauliac

    Montpellier, 34295, France

  • CHRU de Tours - Hôpital Bretonneau

    Tours, 37044, France

  • CHU de Limoges - Hôpital Dupuytren

    Limoges, 87042, France

  • CHU de Nice - Hôpital Pasteur

    Nice, 06002, France

  • CHU de Strasbourg - Hôpital de Hautepierre

    Strasbourg, 67098, France

  • Centre for Neuromuscular Diseases - National Hospital of Neurology

    London, WC1N 3BG, United Kingdom

  • HCL - Hôpital Neurologique P. Wertheimer

    Lyon, 69677, France

  • Institute of Neurological Sciences, Queen Elizabeth University Hospital

    Glasgow, G514TF, United Kingdom

  • King's MND Care and Research Centre

    London, SE5 8AF, United Kingdom

  • North-East London and Essex MND Regional Care Centre

    London, E1 4NS, United Kingdom

  • Salford Royal NHS Foundation Trust, Neurology Dept

    Manchester, M6 8HD, United Kingdom

  • Sheffield Care and Research Centre

    Sheffield, S10 2JF, United Kingdom

  • Trafford Centre for Biomedical Research

    Brighton, BN1 9RY, United Kingdom

Conditions

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