New hope for rare kidney disease: drug targets protein to slow damage
NCT ID NCT07211685
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 27 times
Summary
This study tests an experimental drug called BAY 3401016 in 60 adults aged 18 to 45 with Alport syndrome, a rare genetic condition that leads to kidney failure. The drug blocks a protein thought to cause kidney damage, aiming to reduce protein in the urine and slow the loss of kidney function. Participants receive either the drug or a placebo, and researchers will measure changes over 24 weeks.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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All India Institute of Medical Sciences (AIIMS) - New Delhi
NOT_YET_RECRUITINGNew Delhi, National Capital Territory of Delhi, 110029, India
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Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Necker-Enfants Malades - Service d'Hopital De Jour Néphrologie adulte
NOT_YET_RECRUITINGParis, Île-de-France Region, 75015, France
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Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Nefrologia, Dialisi e Trapianto
RECRUITINGBologna, 40138, Italy
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Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia - Nefrologia
RECRUITINGBrescia, 25123, Italy
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CHU bordeaux - Hopital Pellegrin - Service de Nephrologie-Transplantation-Dialyse-Aphereses
NOT_YET_RECRUITINGBordeaux, New Aquitaine, 33076, France
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CHU de Brest - Hopital La Cavale Blanche - Service de Nephorologie-Hémodialyse-Transplantation
RECRUITINGBrest, Brittany Region, 29200, France
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CHU de Québec-Université Laval
NOT_YET_RECRUITINGQuébec, G1R 2J6, Canada
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CSK U.M. Lodz - Klin. Nefrologii, Hipertensjologii, Transplantologii i Chorób Wewnetrznych Samodz. Publiczny Zaklad OZ
NOT_YET_RECRUITINGLodz, 92-213, Poland
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Cardio Renal Institute
RECRUITINGChubbuck, Idaho, 83202, United States
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Center for Advanced Pediatrics - Nephrology
NOT_YET_RECRUITINGAtlanta, Georgia, 30329, United States
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Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital de Rangueil - Nephrologie et transplantation d'organes
NOT_YET_RECRUITINGToulouse, Occitanie, 31400, France
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Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC)
RECRUITINGCiudad Autonoma de Buenos Aire, Buenos Aires, C1431FWO, Argentina
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Centro de Rehabilitacion Cardiovascular | San Luis, Argentina
RECRUITINGSan Luis, San Luis Province, D5700CGR, Argentina
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Charité Mitte - Nephrologie und Internistische Intensivmedizin
NOT_YET_RECRUITINGBerlin, 10117, Germany
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Children's Hospital of Chongqing Medical University - Department of Nephrology
NOT_YET_RECRUITINGChongqing, Chongqing Municipality, 401122, China
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Children's Hospital, Zhejiang University School of Medicine - Department of Nephrology
RECRUITINGHangzhou, Zhejiang, 310052, China
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Clinica de Nefrologia, Urologia y Enfermedades Cardiovasculares S.A.
RECRUITINGSanta Fe, S3000EPV, Argentina
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Fakultní nemocnice Hradec Kralové - Nefrologická klinika
RECRUITINGHradec Králové, 500 05, Czechia
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Fundacio Puigvert | Nefrologia
NOT_YET_RECRUITINGBarcelona, 8025, Spain
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Hospital Británico
RECRUITINGCiudad Autonoma de Buenos Aire, Buenos Aires, C1280AEB, Argentina
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Hospital General La Mancha Centro | Nephrology
NOT_YET_RECRUITINGAlcázar de San Juan, Ciudad Real, 13600, Spain
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Hospital Universitari Vall D Hebron | Nefrologia
RECRUITINGBarcelona, 08035, Spain
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Hospital Universitario Fundacion Jimenez Diaz | Nephrology and Hypertension Department
RECRUITINGMadrid, 28040, Spain
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Hospital Universitario Virgen Del Rocio S.L. | Nefrologia
NOT_YET_RECRUITINGSeville, 41013, Spain
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Hospital de Curry Cabral - Nephrology Department
NOT_YET_RECRUITINGLisbon, 1069-166, Portugal
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Hospital de Torres Novas - Nephrology Department
NOT_YET_RECRUITINGTorres Novas, 2350-399, Portugal
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IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene
RECRUITINGGenova, 16147, Italy
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Japanese RedCross Aichi Medical Center Nagoya Daini Hospital
RECRUITINGNagoya, Aichi-ken, 466-8650, Japan
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K.G. Hospital
NOT_YET_RECRUITINGCoimbatore, Tamil Nadu, 641018, India
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Kobe University Hospital
NOT_YET_RECRUITINGKobe, 650-0017, Japan
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Lakeridge Health-Oshawa
NOT_YET_RECRUITINGOshawa, Ontario, L1G 2B9, Canada
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Local Incorporated Administrative Agency Osaka City Hospital Organization Osaka City General Hospital
RECRUITINGOsaka, 534-0021, Japan
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London Health Sciences Centre (LHSC) - University Hospital
NOT_YET_RECRUITINGLondon, Ontario, N6A 5A5, Canada
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Mavani Research Center
NOT_YET_RECRUITINGAhmedabad, Gujarat, 380052, India
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McGill University Health Centre - Glen Site
NOT_YET_RECRUITINGMontreal, Quebec, H4A 3J1, Canada
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Nephrology Clinic at The Kirklin Clinic of UAB Hospital
NOT_YET_RECRUITINGBirmingham, Alabama, 35233, United States
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Ospedale Pediatrico Bambino Gesù - Nefrologia
NOT_YET_RECRUITINGRoma, 00165, Italy
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Peking University First Hospital - Department of Pediatrics
RECRUITINGBeijing, Beijing Municipality, 100000, China
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Renal Disease Research Institute | Landry
RECRUITINGDallas, Texas, 75246, United States
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Royal Devon University Healthcare NHS Foundation Trust | Royal Devon and Exeter Hospital - Renal Unit
RECRUITINGExeter, Devon, EX2 5DW, United Kingdom
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Royal Free London NHS Foundation Trust | Royal Free Hospital - Centre for Nephrology
NOT_YET_RECRUITINGLondon, Greater London, NW3 2QG, United Kingdom
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Saitama Prefectural Children's Medical Center
RECRUITINGChuo-Ku, Saitama, 330-8777, Japan
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Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, Gyeonggido, 13620, South Korea
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Seoul National University Hospital
RECRUITINGSeoul, Seoul Teugbyeolsi, 3080, South Korea
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Sheffield Teaching Hospitals NHS Foundation Trust | Northern General Hospital - Sheffield Kidney Institute
NOT_YET_RECRUITINGSheffield, South Yorkshire, S5 7AU, United Kingdom
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South Tyneside and Sunderland NHS Foundation Trust | Sunderland Royal Hospital - Renal Unit
RECRUITINGSunderland, Tyne and Wear, SR4 7TP, United Kingdom
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St. Joseph's Healthcare - Hamilton
RECRUITINGHamilton, Ontario, L8N 4A6, Canada
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The First Affiliated Hospital, Sun Yat-sen University - Department of Pediatrics
RECRUITINGGuangzhou, Guangdong, 510080, China
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The Institute of Post Graduate Medical Education & Research (IPGMER) (SSKM Hospital)
NOT_YET_RECRUITINGKolkata, West Bengal, 700020, India
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The Peggy and Harold Katz Family Drug Discovery Center - Nephrology
NOT_YET_RECRUITINGMiami, Florida, 33136, United States
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Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology - Pediatric Nephrology and Immunology
RECRUITINGWuhan, Hubei, 430205, China
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Tufts Medical Center | Nephrology Department
NOT_YET_RECRUITINGBoston, Massachusetts, 02111, United States
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Unidade Local de Saude de Gaia/Espinho E.P.E Nephrology Department
RECRUITINGVila Nova de Gaia, 4434-502, Portugal
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Unidade Local de Saúde de São João E.P.E. - Hospital São João - Serviço de Nefrologia
RECRUITINGPorto, 4200-319, Portugal
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Universitaetsklinikum Erlangen - Medizinische Klinik 4, Nephrologie, Hypertensiologie
RECRUITINGErlangen, 91054, Germany
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Universitaetsklinikum Koeln - Klinik II fuer Innere Medizin - Nephrologie, Rheumatologie, Diabetologie, Innere Medizin
NOT_YET_RECRUITINGCologne, North Rhine-Westphalia, 50937, Germany
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Universitaetsmedizin Goettingen (UMG) - Klinik fuer Nephrologie und Rheumatologie
NOT_YET_RECRUITINGGöttingen, Lower Saxony, 37075, Germany
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Uniwersytecki Szpital Kliniczny w Poznaniu, Oddzial Kliniczny Nefrologii Transplantologii i Chorob Wewnetrznych
NOT_YET_RECRUITINGPoznan, 60-355, Poland
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Všeobecná fakultní nemocnice v Praze - Klinika nefrologie
NOT_YET_RECRUITINGPrague, 128 08, Czechia
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Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy - Centrum Wsparcia Badan Klinicznych
NOT_YET_RECRUITINGWarsaw, 04-141, Poland
Conditions
Explore the condition pages connected to this study.