New hope for rare kidney disease: drug targets protein to slow damage

NCT ID NCT07211685

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 27 times

Summary

This study tests an experimental drug called BAY 3401016 in 60 adults aged 18 to 45 with Alport syndrome, a rare genetic condition that leads to kidney failure. The drug blocks a protein thought to cause kidney damage, aiming to reduce protein in the urine and slow the loss of kidney function. Participants receive either the drug or a placebo, and researchers will measure changes over 24 weeks.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ALPORT SYNDROME are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • All India Institute of Medical Sciences (AIIMS) - New Delhi

    NOT_YET_RECRUITING

    New Delhi, National Capital Territory of Delhi, 110029, India

  • Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Necker-Enfants Malades - Service d'Hopital De Jour Néphrologie adulte

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75015, France

  • Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Nefrologia, Dialisi e Trapianto

    RECRUITING

    Bologna, 40138, Italy

  • Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia - Nefrologia

    RECRUITING

    Brescia, 25123, Italy

  • CHU bordeaux - Hopital Pellegrin - Service de Nephrologie-Transplantation-Dialyse-Aphereses

    NOT_YET_RECRUITING

    Bordeaux, New Aquitaine, 33076, France

  • CHU de Brest - Hopital La Cavale Blanche - Service de Nephorologie-Hémodialyse-Transplantation

    RECRUITING

    Brest, Brittany Region, 29200, France

  • CHU de Québec-Université Laval

    NOT_YET_RECRUITING

    Québec, G1R 2J6, Canada

  • CSK U.M. Lodz - Klin. Nefrologii, Hipertensjologii, Transplantologii i Chorób Wewnetrznych Samodz. Publiczny Zaklad OZ

    NOT_YET_RECRUITING

    Lodz, 92-213, Poland

  • Cardio Renal Institute

    RECRUITING

    Chubbuck, Idaho, 83202, United States

  • Center for Advanced Pediatrics - Nephrology

    NOT_YET_RECRUITING

    Atlanta, Georgia, 30329, United States

  • Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital de Rangueil - Nephrologie et transplantation d'organes

    NOT_YET_RECRUITING

    Toulouse, Occitanie, 31400, France

  • Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC)

    RECRUITING

    Ciudad Autonoma de Buenos Aire, Buenos Aires, C1431FWO, Argentina

  • Centro de Rehabilitacion Cardiovascular | San Luis, Argentina

    RECRUITING

    San Luis, San Luis Province, D5700CGR, Argentina

  • Charité Mitte - Nephrologie und Internistische Intensivmedizin

    NOT_YET_RECRUITING

    Berlin, 10117, Germany

  • Children's Hospital of Chongqing Medical University - Department of Nephrology

    NOT_YET_RECRUITING

    Chongqing, Chongqing Municipality, 401122, China

  • Children's Hospital, Zhejiang University School of Medicine - Department of Nephrology

    RECRUITING

    Hangzhou, Zhejiang, 310052, China

  • Clinica de Nefrologia, Urologia y Enfermedades Cardiovasculares S.A.

    RECRUITING

    Santa Fe, S3000EPV, Argentina

  • Fakultní nemocnice Hradec Kralové - Nefrologická klinika

    RECRUITING

    Hradec Králové, 500 05, Czechia

  • Fundacio Puigvert | Nefrologia

    NOT_YET_RECRUITING

    Barcelona, 8025, Spain

  • Hospital Británico

    RECRUITING

    Ciudad Autonoma de Buenos Aire, Buenos Aires, C1280AEB, Argentina

  • Hospital General La Mancha Centro | Nephrology

    NOT_YET_RECRUITING

    Alcázar de San Juan, Ciudad Real, 13600, Spain

  • Hospital Universitari Vall D Hebron | Nefrologia

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario Fundacion Jimenez Diaz | Nephrology and Hypertension Department

    RECRUITING

    Madrid, 28040, Spain

  • Hospital Universitario Virgen Del Rocio S.L. | Nefrologia

    NOT_YET_RECRUITING

    Seville, 41013, Spain

  • Hospital de Curry Cabral - Nephrology Department

    NOT_YET_RECRUITING

    Lisbon, 1069-166, Portugal

  • Hospital de Torres Novas - Nephrology Department

    NOT_YET_RECRUITING

    Torres Novas, 2350-399, Portugal

  • IRCCS Istituto Giannina Gaslini - Nefrologia e Trapianto Rene

    RECRUITING

    Genova, 16147, Italy

  • Japanese RedCross Aichi Medical Center Nagoya Daini Hospital

    RECRUITING

    Nagoya, Aichi-ken, 466-8650, Japan

  • K.G. Hospital

    NOT_YET_RECRUITING

    Coimbatore, Tamil Nadu, 641018, India

  • Kobe University Hospital

    NOT_YET_RECRUITING

    Kobe, 650-0017, Japan

  • Lakeridge Health-Oshawa

    NOT_YET_RECRUITING

    Oshawa, Ontario, L1G 2B9, Canada

  • Local Incorporated Administrative Agency Osaka City Hospital Organization Osaka City General Hospital

    RECRUITING

    Osaka, 534-0021, Japan

  • London Health Sciences Centre (LHSC) - University Hospital

    NOT_YET_RECRUITING

    London, Ontario, N6A 5A5, Canada

  • Mavani Research Center

    NOT_YET_RECRUITING

    Ahmedabad, Gujarat, 380052, India

  • McGill University Health Centre - Glen Site

    NOT_YET_RECRUITING

    Montreal, Quebec, H4A 3J1, Canada

  • Nephrology Clinic at The Kirklin Clinic of UAB Hospital

    NOT_YET_RECRUITING

    Birmingham, Alabama, 35233, United States

  • Ospedale Pediatrico Bambino Gesù - Nefrologia

    NOT_YET_RECRUITING

    Roma, 00165, Italy

  • Peking University First Hospital - Department of Pediatrics

    RECRUITING

    Beijing, Beijing Municipality, 100000, China

  • Renal Disease Research Institute | Landry

    RECRUITING

    Dallas, Texas, 75246, United States

  • Royal Devon University Healthcare NHS Foundation Trust | Royal Devon and Exeter Hospital - Renal Unit

    RECRUITING

    Exeter, Devon, EX2 5DW, United Kingdom

  • Royal Free London NHS Foundation Trust | Royal Free Hospital - Centre for Nephrology

    NOT_YET_RECRUITING

    London, Greater London, NW3 2QG, United Kingdom

  • Saitama Prefectural Children's Medical Center

    RECRUITING

    Chuo-Ku, Saitama, 330-8777, Japan

  • Seoul National University Bundang Hospital

    RECRUITING

    Seongnam-si, Gyeonggido, 13620, South Korea

  • Seoul National University Hospital

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 3080, South Korea

  • Sheffield Teaching Hospitals NHS Foundation Trust | Northern General Hospital - Sheffield Kidney Institute

    NOT_YET_RECRUITING

    Sheffield, South Yorkshire, S5 7AU, United Kingdom

  • South Tyneside and Sunderland NHS Foundation Trust | Sunderland Royal Hospital - Renal Unit

    RECRUITING

    Sunderland, Tyne and Wear, SR4 7TP, United Kingdom

  • St. Joseph's Healthcare - Hamilton

    RECRUITING

    Hamilton, Ontario, L8N 4A6, Canada

  • The First Affiliated Hospital, Sun Yat-sen University - Department of Pediatrics

    RECRUITING

    Guangzhou, Guangdong, 510080, China

  • The Institute of Post Graduate Medical Education & Research (IPGMER) (SSKM Hospital)

    NOT_YET_RECRUITING

    Kolkata, West Bengal, 700020, India

  • The Peggy and Harold Katz Family Drug Discovery Center - Nephrology

    NOT_YET_RECRUITING

    Miami, Florida, 33136, United States

  • Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology - Pediatric Nephrology and Immunology

    RECRUITING

    Wuhan, Hubei, 430205, China

  • Tufts Medical Center | Nephrology Department

    NOT_YET_RECRUITING

    Boston, Massachusetts, 02111, United States

  • Unidade Local de Saude de Gaia/Espinho E.P.E Nephrology Department

    RECRUITING

    Vila Nova de Gaia, 4434-502, Portugal

  • Unidade Local de Saúde de São João E.P.E. - Hospital São João - Serviço de Nefrologia

    RECRUITING

    Porto, 4200-319, Portugal

  • Universitaetsklinikum Erlangen - Medizinische Klinik 4, Nephrologie, Hypertensiologie

    RECRUITING

    Erlangen, 91054, Germany

  • Universitaetsklinikum Koeln - Klinik II fuer Innere Medizin - Nephrologie, Rheumatologie, Diabetologie, Innere Medizin

    NOT_YET_RECRUITING

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Universitaetsmedizin Goettingen (UMG) - Klinik fuer Nephrologie und Rheumatologie

    NOT_YET_RECRUITING

    Göttingen, Lower Saxony, 37075, Germany

  • Uniwersytecki Szpital Kliniczny w Poznaniu, Oddzial Kliniczny Nefrologii Transplantologii i Chorob Wewnetrznych

    NOT_YET_RECRUITING

    Poznan, 60-355, Poland

  • Všeobecná fakultní nemocnice v Praze - Klinika nefrologie

    NOT_YET_RECRUITING

    Prague, 128 08, Czechia

  • Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy - Centrum Wsparcia Badan Klinicznych

    NOT_YET_RECRUITING

    Warsaw, 04-141, Poland

Conditions

Explore the condition pages connected to this study.