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Can exercise shield the brain from Parkinson's?

NCT ID NCT07882446

Prevention Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 20, 2026 · Last updated Oct 21, 2026 · Updated 1 time

Summary

Researchers test whether a structured aerobic exercise program can delay or prevent motor and cognitive decline in adults at high risk of developing Parkinson's disease. The trial enrolls people aged 55 to 65 who are identified as high-risk for Parkinson's within the next 24 months. Participants use a stationary bike at home, and researchers measure changes in motor symptoms, walking speed, and sense of smell.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a structured aerobic exercise program using a stationary bike
What this could lead to
If it works, this could offer a low-cost, drug-free way to delay or prevent Parkinson's symptoms in people at high risk.
What could go wrong
The trial is small and early, so it may not show a clear benefit. Exercise programs also require regular commitment, and some people may find the bike difficult to use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult identified as high-risk for developing PD within the next 24 months 2. Age 55-65 years 3. Demonstrate the ability to safely mount and dismount the Peloton stationary cycle 4. In-home WiFi (Peloton system requires WiFi to transmit exercise data) Exclusion Criteria: 1. Diagnosis of neurocognitive impairment that compromises one's ability to provide informed consent. 2. A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in aerobic exercise 3. Neurological disease (i.e. multiple sclerosis, PD, stroke, etc.) 4. Current cardiac arrhythmia 5. Greater than 3 weeks of consecutive time away from home that would render the individual unable to complete the cycling protocol 6. Recommendation for medical clearance using the American College of Sports Medicine (ACSM) Preparticipation Health Screen4 * If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provider prior to participation. * Those who choose not to obtain physician clearance will not be eligible for participation. Those who do not receive physician clearance for high intensity exercise will not be eligible.

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Conditions

The condition(s) this trial relates to.

Motor Activity Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson's disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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