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Comprehensive analysis of quality and outcomes in thyroid surgery using Real-World clinical data

NCT ID NCT07812779

NEW Sponsor: Pirogov Russian National Research Medical University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 10, 2026

Summary

THORS is a single-center ambidirectional observational cohort study conducted at Moscow Multidisciplinary Clinical Center "Kommunarka". The study combines retrospective analysis of routinely collected clinical data from patients who underwent thyroid surgery beginning in January 2023 with ongoing prospective accrual of new eligible patients and longitudinal updating of follow-up information. No diagnostic or therapeutic intervention is assigned by the research protocol; all treatment decisions are made as part of routine clinical care. The program evaluates the structure and outcomes of thyroid surgery, postoperative complications, histopathology, repeat and completion procedures, long-term oncologic and functional outcomes, health-care resource use, and the quality and reproducibility of real-world data. Applicable outcomes from the international Core Outcome Set for surgical treatment of differentiated thyroid carcinoma (COS-DTC) are incorporated where they can be reliably measured. The first frozen historical analytical baseline includes 968 unique patients and 1,017 thyroid operations performed from 06 January 2023 through 13 February 2026. The cohort remains open to ongoing enrollment and follow-up

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jan 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients treated surgically for benign or malignant thyroid disease at a single multidisciplinary medical center in Moscow. The population is identified from routine clinical-care data and includes historical patients as well as newly accrued eligible patients. Primary, completion, and repeat thyroid operations are eligible when the relevant data can be linked and the episode meets the specific substudy requirements.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient undergoes or previously underwent an operation involving the thyroid gland at the study institution during the study period. * The operation was performed for a benign or malignant thyroid disease, including primary, completion, or repeat thyroid surgery. * Source data permit linkage of the patient, hospitalization, operation, and index date. * For a specific substudy, the participant/episode meets the additional prespecified requirements for the relevant exposure and outcome. Exclusion Criteria: \- Procedure predominantly involving the parathyroid glands without a confirmed relationship to thyroid disease. * Procedure or record without a confirmed relationship to thyroid disease. * Technical duplicate record. * Episode for which the essential temporal sequence or index date cannot be established for the relevant analysis. * Record lacking the minimum data required to determine the primary outcome of the specific substudy.

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Conditions

The condition(s) this trial relates to.

adrenal gland cancer adrenal gland neoplasm Carcinoma, Medullary familial medullary thyroid carcinoma goiter Postoperative Complications thyroid cancer thyroid gland disorder Thyroid Neoplasms Thyroid Nodule thyroid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adrenal cancer Adrenal gland neoplasms Endocrine surgery Goiter Medullary thyroid carcinoma Neck dissection Real-world data Thyroid cancer Thyroid diseases Thyroid neoplasms Thyroid nodules Thyroid surgery for benign disease

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

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