Brain study targets motivation problems in depressed teens

NCT ID NCT05487885

First seen Apr 04, 2026 · Last updated May 24, 2026 · Updated 8 times

Summary

This study looked at anhedonia—a lack of motivation or pleasure—in 123 young people with depression. Participants had brain scans, blood tests, and interviews to measure symptoms. Some also tried treatments like brain stimulation (TMS), positive thinking training, or ketamine. The goal was to better understand anhedonia and find new ways to help those who don't improve with standard depression treatments.

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Contacts and locations

Locations

  • Loeffler Building

    Pittsburgh, Pennsylvania, 15213, United States

Conditions

Explore the condition pages connected to this study.