Can shrinking radiation margins spare lungs without sacrificing cancer control?
NCT ID NCT06542159
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether using real-time adaptive radiation without the usual safety margin can reduce lung side effects in people with early-stage non-small cell lung cancer or limited lung metastases. About 130 participants will be randomly assigned to either standard radiation or the new adaptive technique. The main goal is to see if the new method lowers the chance of breathing problems while still controlling the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy (online adaptive stereotactic body radiotherapy without PTV expansion margin)
What this could lead to
If successful, this approach could reduce breathing-related side effects from radiation while still effectively controlling early-stage lung cancer or limited lung metastases.
What could go wrong
This is a phase II trial with only 130 participants, so results are preliminary. Removing safety margins might increase the risk of missing the tumor, and the technique requires specialized equipment not widely available.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Sun yat-sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
Contact Phone: •••-•••-•••• Email: •••••@•••••