Melanoma drug combo gets a smarter schedule

NCT ID NCT03543969

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 29 times

Summary

This early-phase study tested a new way of giving three drugs (encorafenib, binimetinib, and nivolumab) to people with advanced BRAF-mutant melanoma. Instead of taking the drugs every day, participants followed an on/off schedule to see if it could control the cancer while reducing side effects. The study enrolled 14 adults with stage IIIC to IV melanoma that could not be removed by surgery.

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Contacts and locations

Locations

  • H. Lee Moffitt Cancer Center and Research Institute

    Tampa, Florida, 33612, United States

Conditions

Explore the condition pages connected to this study.