Can a dissolvable glue seal the brain and stop leaks after surgery?
NCT ID NCT07768553
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This clinical trial is testing whether a new absorbable adhesive can help seal the protective lining of the brain (the dura) after neurosurgery, preventing cerebrospinal fluid leaks. The study involves 132 adults who are having brain or spinal surgery and are at risk of such leaks. Participants are randomly assigned to receive either the new adhesive or an existing sealing film, and the success of the seal is checked about a week after surgery. The goal is to see if the new adhesive works as well as the current option, with fewer complications.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- An absorbable medical adhesive made of polyethylene glycol (PEG) derivatives that forms a hydrogel to seal the dura during neurosurgery.
- What this could lead to
- If effective, this adhesive could offer a new way to prevent cerebrospinal fluid leaks after brain or spinal surgery, potentially reducing complications and the need for additional procedures.
- What could go wrong
- This is a Phase 3 trial with a relatively small number of participants (132). The adhesive may not be as effective as the existing sealing film, and there are risks of infection, swelling, or other surgical complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CEREBROSPINAL FLUID LEAK are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
-
Huazhong University of Science and Technology Union Shenzhen Hospital (Shenzhen Nanshan People's Hospital)
Shenzhen, Guangdong, China
-
Qinghai Provincial People's Hospital
Xining, Qinghai, China
-
Shenzhen Second People's Hospital
Shenzhen, Guangdong, China
-
Tangdu Hospital, Air Force Medical University
Xi'an, Shaanxi, China
-
The Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
-
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
-
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
-
The Second Affiliated Hospital of Shantou University Medical College
Shantou, Guangdong, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.