A toothpaste designed for aging mouths takes on bad breath

NCT ID NCT07780474

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial compares a toothpaste made for adults 50 and older with a standard fluoride toothpaste to see which better reduces bad breath. About 30 orally healthy adults aged 18 to 65 will use each toothpaste for 14 days, with a break in between, in a random order. Neither participants nor examiners will know which toothpaste is being used. The study measures breath sulfur compounds, tongue coating, dry mouth, saliva, and comfort, asking whether the 50+ formula offers an edge in oral freshness and comfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A toothpaste formulated for adults aged 50 years and older (Biorepair Advanced Complete Protection 50+ Toothpaste)
What this could lead to
If it works, this toothpaste could offer a simple, everyday way for older adults to reduce bad breath and improve oral comfort.
What could go wrong
This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The toothpaste may not outperform the standard one, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 65 years. * Male or female. * Orally healthy according to clinical examination, with no active oral condition that could interfere with study outcomes. * At least 20 natural teeth. * No active periodontitis. * No clinically relevant untreated cavitated caries. * No acute oral mucosal disease. * Any existing systemic condition must be stable, controlled, and considered unlikely to interfere with the study outcomes. * Willingness to use only the oral care products provided during each treatment period. * Willingness to refrain from oral hygiene procedures for 24 hours before each assessment visit. * Willingness to refrain from food, beverages other than water, smoking, chewing gum, candies, oral sprays, mouthwashes, and oral hygiene procedures for 3 to 4 hours before each assessment. * Ability to understand the study objectives and procedures. * Provision of written informed consent. Exclusion Criteria: * Active oral or dental disease that could interfere with the study outcomes. Active periodontitis. * Periodontal probing depths greater than 3 mm at multiple sites, according to clinical judgment. * Clinically relevant generalized gingival bleeding. * Clinically relevant untreated cavitated caries. * Oral candidiasis. * Oral ulceration, stomatitis, symptomatic oral mucosal lesions, or acute oral infection. * Clinical signs of severe xerostomia or pathological hyposalivation. * Fewer than 20 natural teeth. * Acute systemic disease or uncontrolled chronic systemic disease. Uncontrolled diabetes mellitus. * Active autoimmune or systemic inflammatory disease. * Gastrointestinal, respiratory, otorhinolaryngological, or metabolic conditions associated with clinically significant extraoral halitosis. * Use of systemic antibiotics within 4 weeks before enrollment. * Habitual use of antiseptic mouthwashes, anti-halitosis products, or dry-mouth products within 2 weeks before enrollment. * Use of medications with a strong xerostomic effect that, in the investigator's judgment, could interfere with study outcomes. * Smoking more than 10 cigarettes per day. * Inability to refrain from smoking for 3 to 4 hours before assessment visits. * Pregnancy or breastfeeding. * Known or suspected allergy to any component of the study products. * Professional dental cleaning or invasive dental procedures within 2 weeks before enrollment. * Inability or unwillingness to comply with the study procedures. * Participation in another clinical study within 4 weeks before enrollment.

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Conditions

The condition(s) this trial relates to.

Halitosis Xerostomia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia

    Pavia, Lombardy, 27100, Italy

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