Could a common cancer drug help tear duct surgery succeed?
NCT ID NCT07154121
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether applying 5-fluorouracil (5-FU) during tear duct surgery can improve success for people with a small tear sac and blocked tear ducts. The trial will enroll 100 adults who need endoscopic dacryocystorhinostomy (En-DCR). Half will get standard surgery plus a 5-FU-soaked sponge at the surgical site; the other half will get standard surgery plus saline. Success is measured by symptom relief and a clear tear duct at six months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 5-fluorouracil (5-FU)
- What this could lead to
- If it works, this could offer a simple, low-cost way to improve surgical success for people with a small tear sac and blocked tear ducts.
- What could go wrong
- This is a small, early-phase trial with only 100 participants. The drug is applied during surgery, but it may not improve outcomes and could cause side effects like irritation or delayed healing.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zhongshan Ophthalmic Center
RECRUITINGGuangzhou, Guangdong, 510060, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.