New radioactive drug targets Hard-to-Treat prostate cancer

NCT ID NCT06217822

Recruiting now Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This early-stage study tests a new drug, 225Ac-PSMA-Trillium, in people with advanced prostate cancer that has spread and no longer responds to hormone therapy. The drug delivers radiation directly to cancer cells to damage them. The main goals are to check safety, find the best dose, and see if it shrinks tumors or lowers PSA levels. About 198 participants will receive up to 4 doses, given every 6 to 8 weeks.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED METASTATIC CASTRATION-RESISTANT PROSTATE CANCER PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) EXPRESSION

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AZ Groeninge Campus Kennedylaan - Urology
RECRUITING

Kortrijk, West Flanders, 8500, Belgium
Akademiska sjukhuset i Uppsala - Fas 1-enheten
SUSPENDED

Uppsala, Uppsala County, 751 85, Sweden
BC Cancer | Vancouver
RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Centre Hospitalier de l'Universite de Montreal (CHUM) | Oncology
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Centre hospitalier universitaire de Sherbrooke (CHUS) | Oncology
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
City of Hope - Duarte Cancer Center
NOT_YET_RECRUITING

Duarte, California, 91010, United States
Cross Cancer Institute | Clinical Trials Unit
WITHDRAWN

Edmonton, Alberta, T6G 1Z2, Canada
Docrates Mehiläinen Syöpäsairaala
RECRUITING

Helsinki, Uusimaa, 00180, Finland
Erasmus Medisch Centrum
WITHDRAWN

Rotterdam, South Holland, 3015 CE, Netherlands
HUS-Yhtymä, Helsingin yliopistollinen sairaala (HUS) - Syöpäkeskus
RECRUITING

Helsinki, Uusimaa, 00029, Finland
IRCCS Istituto Nazionale Tumori Fondazione Pascale - S. C. Medicina Nucleare e Terapia Metabolica
NOT_YET_RECRUITING

Naples, 80131, Italy
Institut Jules Bordet / Nuclear Medicine
RECRUITING

Anderlecht, Brussels Capital, 1070, Belgium
Istituto Europeo di Oncologia s.r.l - Medicina Nucleare
RECRUITING

Milan, 20141, Italy
Juravinski Cancer Centre | Clinical Trials
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Kantonsspital Baden
WITHDRAWN

Baden, Canton of Aargau, 5404, Switzerland
Karolinska Universitetssjukhuset - Solna - Fas I-enheten Solna CKC
RECRUITING

Stockholm, Stockholm County, 171 76, Sweden
Kuopio University Hospital, Kuopion yliopistollinen sairaala (KYS) - Syövänhoitokeskus
RECRUITING

Kuopio, Northern Savonia, 70210, Finland
M Health Fairview Masonic Cancer Clinic - Clinics and Surgery Center
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55455, United States
Princess Margaret Cancer Centre - University Health Network - Department of Medical Oncology and Hematology
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
Research Institute of the McGill University Health Centre | McConnell Centre for Innovative Medicine
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Sahlgrenska Universitetssjukhuset - Sahlgrenska Sjukhuset - Klinisk prövningsenhet Fas I/FIH
RECRUITING

Gothenburg, Västra Götaland County, 413 46, Sweden
Skånes Universitetssjukhus - Lund - Onkologens kliniska forskningsenhet
RECRUITING

Lund, Skåne County, 221 85, Sweden
Tampere University Hospital, Tampereen yliopistollinen sairaala (TAYS) - Syöpäkeskus
SUSPENDED

Tampere, Pirkanmaa, 33520, Finland
The Cancer Institute Hospital of JFCR
NOT_YET_RECRUITING

Koto-ku, Tokyo, 135-8550, Japan
The Newcastle upon Tyne Hospitals NHS Foundation Trust | Freeman Hospital - Cancer Trials Research Centre
NOT_YET_RECRUITING

Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom
The Royal Marsden NHS Foundation Trust | Sutton - Oak Foundation Drug Development Unit
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
The University of Texas MD Anderson Cancer Center - Texas Medical Center
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Turku University Hospital, Turun yliopistollinen sairaala (TYKS) - Syöpäkeskus
RECRUITING

Turku, Southwest Finland, 20540, Finland
UZ Leuven - Campus Gasthuisberg - Nuclear Medicine
NOT_YET_RECRUITING

Leuven, Flemish Brabant, 3000, Belgium
Universitair Medisch Centrum Groningen (UMCG) - UMC Groningen Comprehensive Cancer Center
RECRUITING

Groningen, 9713 GZ, Netherlands
University College London Hospitals NHS Foundation Trust | University College Hospital - NIHR UCLH Clinical Research Facility
RECRUITING

London, Greater London, W1T 7HA, United Kingdom
UniversitätsSpital Zürich (USZ) - Klinik für Medizinische Onkologie und Hämatologie
RECRUITING

Zurich, 8091, Switzerland
Universitätsspital Basel
NOT_YET_RECRUITING

Basel, Canton of Basel-City, 4056, Switzerland
XCancer Omaha
NOT_YET_RECRUITING

Omaha, Nebraska, 68130, United States
Yokohama City University Hospital
NOT_YET_RECRUITING

Yokohama, Kanagawa, 236-0004, Japan

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