Xinhua Hospital, Shanghai Jiao Tong University School Of Medicine

This trial tests an experimental gene therapy called MWAV201 in adults with Wilson disease, a genetic condition that causes copper to build up in the body. The treatment uses a harmless virus to deliver a corrected gene, potentially restoring the body's ability to remove copper. …

This trial tests whether a smartphone app and remote diet/exercise coaching can help people with non-alcoholic fatty liver disease lose weight and reduce liver fat. 120 participants will either get standard lifestyle advice or use the app with daily meal tracking, weekly recipe a…

This phase 2 trial tests whether empagliflozin, a diabetes drug also known as Jardiance, can help people with glycogen storage disease type Ib (GSD-1b). GSD-1b causes low neutrophil counts, leading to frequent infections and bowel inflammation. The study gives empagliflozin orall…

This study tests whether giving melatonin to pregnant women with a severe form of fetal growth restriction can help their babies. The trial will involve 240 women who will take either melatonin or a placebo nightly. Researchers will track baby growth, pregnancy length, and newbor…

This study tests a new approach for people with locally advanced rectal cancer that has a common genetic profile (MSS/pMMR). Instead of standard radiation before surgery, participants receive a combination of chemotherapy (mFOLFOX6) and an immunotherapy drug (PD-1 antibody). The …

This study tests a new combination of chemotherapy and two immunotherapy drugs in people with advanced gallbladder cancer that cannot be removed by surgery. The goal is to see if the treatment can shrink tumors enough to allow surgery or improve response. About 44 adults aged 18-…

This trial is testing whether a dry blood spot test—using a tiny sample from a newborn's heel—can screen for biliary atresia, a serious liver condition that blocks bile flow. The test measures certain biomarkers (direct bilirubin, γ-GT, and MMP-7) that may be elevated in affected…

This trial is developing an artificial intelligence system that reads electrocardiograms (ECGs) to detect congenital heart disease in children. Researchers are collecting ECG data from thousands of children, including those with common and rare heart defects, to train a deep-lear…

This study compares two imaging methods—multiparametric ultrasound (mpUS) and multiparametric MRI (mpMRI)—to see which better detects clinically significant prostate cancer in men scheduled for their first biopsy. Participants receive both scans before biopsy, and if either shows…

This study looks at children diagnosed with a ventricular septal defect (a hole in the heart) to understand if and when the hole might close without treatment. Researchers will follow children from birth to age 14 and use echocardiography to track the defect. The goal is to build…

This study explores whether artificial intelligence can predict which children with a type of heart hole (perimembranous ventricular septal defect) will later develop complications like valve problems or blockages. Researchers will analyze past echocardiogram reports and medical …

This study looks for biological markers in the body that could warn athletes about potential injuries before they happen. Researchers will use advanced technology to analyze samples from 60 athletes aged 12-30 who have had a recent sports injury. The goal is to find patterns that…