University Hospital Southampton Nhs Foundation Trust

This study looks at whether adding the drug acalabrutinib to standard chemotherapy (R-CHOP) helps people with untreated diffuse large B-cell lymphoma live longer without their cancer getting worse. About 450 adults will receive one round of standard chemo, then two-thirds will al…

This study tests whether giving a single dose of radiation directly to the tumor area during surgery is feasible for people with advanced or recurrent rectal cancer. About 31 participants will be randomly assigned to receive standard surgery, surgery plus a standard radiation dos…

This early-stage study tests a combination of three drugs (radioactive therapy, an immunotherapy, and a checkpoint inhibitor) in children whose neuroblastoma has returned or not responded to standard treatment. The main goal is to see if the combination is safe and tolerable. Abo…

This study looks at whether a new way of analyzing MRI brain scans, called Cortical Disarray Measurement (CDM), can help doctors better diagnose Alzheimer's disease. Researchers will follow 400 people with mild memory or thinking problems over time to see if CDM changes match cha…