Solti Breast Cancer Research Group

This study tests whether a combination of two drugs (ribociclib and letrozole) can replace chemotherapy for people with a high-risk type of breast cancer (ER+/HER2-). About 1,100 participants take the drugs before and after surgery. The goal is to see if those who respond well ca…

This study tests a combination of three drugs (atezolizumab, trastuzumab, and vinorelbine) in people with advanced HER2-positive breast cancer that has stopped responding to standard treatments. The goal is to see if this mix can shrink tumors. About 55 participants will receive …

This study looks at tumor and blood samples from 180 people with metastatic cancer who have been treated with the drug trastuzumab deruxtecan (T-DXd). The goal is to find a specific genetic marker (ERBB2 mRNA level) that can predict how well a patient will respond to the drug. No…