Qingyuan Zhan

This phase 3 trial tests whether adding corticosteroids (methylprednisolone) to standard care can reduce deaths in adults with severe adenovirus pneumonia in the ICU. The study compares low and moderate doses against a placebo (saline). It aims to enroll 262 critically ill patien…

This study tests whether adding corticosteroids to standard antibiotic care can lower the risk of death in adults with severe psittacosis (parrot fever) pneumonia in the ICU. About 100 participants will receive either standard care alone or standard care plus different doses of s…

This phase 3 trial will test whether adding low or moderate doses of the corticosteroid methylprednisolone to standard care can lower the death rate in adults with severe influenza pneumonia in the ICU. About 496 participants will be randomly assigned to receive either saline (pl…

This study tests whether giving steroids based on a patient's immune status can reduce deaths in severe pneumonia with respiratory failure. About 500 ICU patients will receive methylprednisolone, with doses adjusted according to their inflammatory profile. The goal is to find out…

This study tests whether adding corticosteroids (low or moderate dose) to standard care can reduce deaths from severe Pneumocystis pneumonia (PJP) in non-HIV patients in the ICU. PJP has a very high death rate of 60-80% in this group. The trial will compare two steroid doses agai…

This trial tests whether low or moderate doses of the steroid methylprednisolone can reduce deaths in patients with severe community-acquired pneumonia. It will enroll 1500 ICU patients with pneumonia caused by adenovirus or Pneumocystis jirovecii. The study uses an adaptive desi…