Principia Biopharma, A Sanofi Company

This study tested an experimental oral drug called rilzabrutinib in 86 adults with relapsed immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, raising bleeding risk. The drug aims to block a key immune signal to help raise platelet counts. The …

This study tested a new drug called rilzabrutinib combined with steroids in 27 adults with active IgG4-related disease, a rare condition causing inflammation and organ damage. The goal was to see if the combination could prevent disease flares better than steroids alone. Particip…

This study tested a new topical gel called PRN473 (SAR444727) in 39 adults with mild to moderate atopic dermatitis (eczema). Each participant had two similar patches of eczema treated: one with the study gel and one with a placebo gel, without knowing which was which. The main go…

This early-stage study tested how taking rilzabrutinib with or without food, and in different pill forms, changes the drug levels in the body. Twenty-four healthy volunteers each received a single dose. The goal was to find the best way to give the drug in future trials, not to t…