Merck Healthcare Kgaa, Darmstadt, Germany, An Affiliate Of Merck Kgaa, Darmstadt, Germany

This study followed 105 people with advanced kidney cancer to see how well avelumab plus axitinib works as their first treatment in real-life settings. Researchers measured survival rates and side effects over 12 months. The goal was to understand the treatment's effectiveness ou…

This study looked at how safe and effective avelumab is as a maintenance treatment for adults with advanced bladder cancer that hasn't gotten worse after initial chemotherapy. Over 100 participants received avelumab in real-world settings and were followed for about 4 years. The …

This study tested whether a single dose of two drugs (M5717 and pyronaridine) can clear the malaria parasite from the blood and protect against future infection. It involved 192 adults and teens with no symptoms but confirmed malaria. The goal was to see how long protection lasts…

This study looked at how the experimental drug evobrutinib affects the way the body handles four common medications: digoxin, metformin, rosuvastatin, and sumatriptan. Forty healthy adults took evobrutinib along with these drugs so researchers could measure changes in drug levels…

This study looked at how a drug called evobrutinib changes the levels of a common birth control pill in the body. Twenty healthy women took both medications and had their blood tested. The goal was to see if evobrutinib affects how the body processes birth control, which helps do…

This study looked at how taking multiple doses of carbamazepine changes the amount of evobrutinib in the blood of 14 healthy adults. Participants stayed at a research unit for 20 days and took both drugs in a set order. The goal was to measure drug levels and check for side effec…

This study tested whether different manufacturing batches of the drug evobrutinib are absorbed similarly in the body. Twenty-eight healthy adults took single doses of different batches, and researchers measured drug levels in the blood and monitored for side effects. The goal was…

This study looked at how different levels of kidney function affect the way the body handles a drug called enpatoran. 34 adults with normal or impaired kidneys received a single dose. Researchers measured drug levels in the blood and checked for side effects. The goal was to unde…

This study looked at how the fertility drug Pergoveris is absorbed and processed in the body of 24 healthy women of Japanese or Caucasian origin. Participants took the drug once after a month of hormone suppression. The goal was to measure drug levels and safety, not to treat inf…

This study looked at how the drug evobrutinib is processed in people with different levels of liver function. 24 adults with either normal or impaired liver function received a single dose. The goal was to understand how liver health affects drug levels and safety.

This study looked at how the experimental drug tuvusertib is absorbed, broken down, and removed from the body in 12 people with advanced solid tumors. Participants received the drug by mouth and by IV with a tiny radioactive marker to track it. The main goal was to understand the…

This study checked whether a single dose of evobrutinib affects the heart's electrical activity (QT interval) in 36 healthy adults. Participants received evobrutinib, a placebo, or a control drug in random order. The goal was purely to gather safety information, not to treat any …

This study looked at whether a wearable sensor (like a smartwatch) can help track symptoms and predict sudden worsening of COPD. 77 people with COPD wore the device for 3 months, while a small group without COPD wore it for 2 weeks. The goal was to see if data like heart rate, ac…