Merck Healthcare Kgaa, Darmstadt, Germany, An Affiliate Of Merck Kgaa, Darmstadt, Germany

This study observed how well the drug Avelumab worked in real-world settings for adults with advanced bladder cancer. It included 106 patients whose cancer had not worsened after initial chemotherapy and who then received Avelumab as a standard maintenance therapy. The goal was t…

This study looked at how well a combination of two existing drugs (avelumab and axitinib) worked for people with advanced kidney cancer in real-world European clinics. It followed 105 patients to see how long they lived, if their tumors shrank, and what side effects they experien…

This study tested whether a single dose of two drugs (M5717 and pyronaridine) could clear existing silent malaria infections and then protect people from getting infected again. It involved 192 asymptomatic adults and adolescents who already had the malaria parasite in their bloo…

This study aimed to understand how a specific fertility drug combination is processed in the body. It involved 24 healthy premenopausal women, half of Japanese origin and half of Caucasian origin. Researchers gave a single injection of the drug and then closely monitored its leve…

This early-stage study aimed to understand how a new drug called evobrutinib might change the way the body processes four other common medications: digoxin (for heart conditions), metformin (for diabetes), rosuvastatin (for cholesterol), and sumatriptan (for migraines). The study…

This study tested whether different manufacturing batches of the same drug, evobrutinib, are absorbed by the body in the same way. It involved 28 healthy volunteers who took the drug on an empty stomach. Researchers measured the drug levels in the blood and checked for side effec…

This study tested whether a single dose of the drug evobrutinib causes any unwanted changes in heart rhythm, specifically the QT interval on an ECG. It involved 36 healthy adult volunteers who received the drug, a placebo, and a control medication in a random order. The main goal…

This study aimed to understand how taking carbamazepine (an existing medication) affects how the body processes a single dose of a new drug called evobrutinib. It involved 14 healthy participants who stayed in a research unit for observation. The main goal was to measure drug lev…

This study tested whether data from a wearable sensor patch could help monitor chronic obstructive pulmonary disease (COPD) and predict symptom flare-ups. For three months, 77 people with COPD wore a patch that tracked things like activity, heart rate, breathing, and coughs. Rese…

This small, completed study aimed to understand how liver problems affect how the body processes a drug called evobrutinib. It involved 24 people, some with healthy livers and some with mild or moderate liver impairment. Each participant received a single dose so researchers coul…

This study aimed to see if taking a new drug called evobrutinib changes how the body processes a common birth control pill. Twenty healthy female participants took both the new drug and the birth control pill for a short period while living at a research clinic. Researchers measu…