Merck Healthcare Kgaa, Darmstadt, Germany, An Affiliate Of Merck Kgaa, Darmstadt, Germany

This completed study looked at how well avelumab (BAVENCIO) plus axitinib (INLYTA) works for advanced kidney cancer in everyday medical practice. Researchers tracked 105 patients across multiple EU countries to see survival rates at 12 and 24 months. The goal was to understand th…

This study tested whether a single dose of two antimalarial drugs, M5717 and pyronaridine, can clear the malaria parasite from the blood and prevent new infections in people who have the parasite but no symptoms. 192 adults and adolescents in malaria-endemic areas took part. The …

This study looked at 106 adults with advanced bladder cancer that hadn't gotten worse after initial chemotherapy. They received avelumab as a maintenance treatment to help keep the cancer under control. Researchers tracked how long patients lived and any side effects in real-worl…

This study looked at how different levels of kidney function affect the way the drug enpatoran moves through the body. 34 adults with normal or impaired kidney function received a single dose of enpatoran. Researchers measured drug levels in the blood and monitored for side effec…

This study looked at how the drug tuvusertib is absorbed, broken down, and removed from the body in 12 people with advanced solid tumors. Participants received a tiny radioactive tracer to track the drug. The main goal was to understand the drug's path in the body, not to treat t…

This completed phase 1 study looked at how the fertility drug Pergoveris (a combination of two hormones, FSH and LH) is processed in the body of 24 healthy premenopausal women of Japanese or Caucasian origin. Participants took a birth control pill for about 4 weeks to suppress th…

This study tested whether a wearable device (Vivalink) could track health signs like heart rate, breathing, and activity in people with COPD. 77 participants wore the device for 3 months to see if the data could predict when symptoms would get worse. The goal was to find a way to…

This study looked at how taking multiple doses of carbamazepine changes the way the body processes a single dose of evobrutinib. Fourteen healthy adults participated, staying at a research unit for 20 days. The goal was to measure drug levels in the blood and check for side effec…

This study looked at how the body absorbs and processes different manufacturing batches of an experimental tablet called evobrutinib. Twenty-eight healthy adults took a single dose of each batch, and researchers measured drug levels in the blood and checked for side effects. The …

This completed Phase 1 study tested how multiple doses of evobrutinib, an experimental drug, affect the way the body processes four common medications: digoxin, metformin, rosuvastatin, and sumatriptan. Forty healthy adults participated in two parts, receiving evobrutinib along w…

This study looked at how a drug called evobrutinib changes the way birth control pills work in 20 healthy women. Participants took both medications and had their blood tested to measure hormone levels. The goal was to see if evobrutinib affects how the body processes birth contro…

This study checked whether a single dose of evobrutinib affects the heart's electrical activity (QT interval) in 36 healthy adults. Participants received evobrutinib, a placebo, or a control drug in random order. The goal was to gather safety information, not to treat any disease…

This study looked at how different levels of liver impairment affect the way the body processes a single dose of the drug evobrutinib. Twenty-four participants with either normal liver function or mild to moderate liver impairment took one dose of the drug. Researchers measured d…