Institut De Recherches Internationales Servier

This early-phase study tested an oral drug called AG-881 in 95 adults with advanced solid tumors, including brain tumors (gliomas), that have specific IDH gene mutations. The main goals were to check safety, find the best dose, and see how the drug works in the body. While not a …

This study tested a combination of four chemotherapy drugs (irinotecan liposome, oxaliplatin, 5-FU, and leucovorin) in 41 Japanese patients with metastatic pancreatic cancer who had not received prior treatment. The goal was to see how well the drugs shrank tumors and to check fo…

This early-phase trial tested an oral drug called AG-120 in 174 people with advanced solid tumors (including bile duct cancer, cartilage cancer, and brain tumors) that have a specific IDH1 gene mutation. The goal was to find a safe dose and check how the drug works in the body. P…

This study tested two experimental drugs, AG-120 and AG-881, in 49 adults with a returning low-grade brain tumor (glioma) that has a specific IDH1 mutation. Participants took the drugs for a short time before their scheduled surgery to see if the drugs could lower a substance cal…