This study tested whether rinsing the tooth with cold saline (cryotherapy) or placing metformin (a diabetes drug) inside the tooth can reduce pain after root canal treatment. 80 adults with infected lower premolars were randomly assigned to receive one of four treatments. Pain wa…
Phase: PHASE2 • Sponsor: Celalettin Topbaş • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC