STAGE IIIC RECTAL CANCER AJCC V8
Clinical trials for STAGE IIIC RECTAL CANCER AJCC V8 explained in plain language.
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New drug cocktail shows promise for Tough-to-Treat colorectal cancer
Disease control OngoingThis study tests a combination of three drugs (cetuximab, LY3214996, and abemaciclib) in people with advanced colorectal cancer that has spread and no longer responds to standard therapy. The goal is to see if the combination can shrink tumors and improve survival. About 46 adult…
Matched conditions: STAGE IIIC RECTAL CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 16, 2026 22:36 UTC
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New combo therapy targets hard-to-treat colorectal cancer
Disease control OngoingThis study tests a new drug, SX-682, alone and with the immunotherapy nivolumab, in people with a specific type of advanced colorectal cancer that has spread or cannot be removed. The cancer must have a RAS mutation and be microsatellite stable (MSS), which often makes it harder …
Matched conditions: STAGE IIIC RECTAL CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 15, 2026 19:06 UTC
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New drug combo aims to shrink rectal tumors before surgery
Disease control OngoingThis early-stage study tests the safety of combining the chemotherapy drug TAS-102 with radiation therapy for people with stage II or III rectal cancer that hasn't been treated yet. The goal is to find the safest dose of TAS-102 to use with radiation before surgery to remove the …
Matched conditions: STAGE IIIC RECTAL CANCER AJCC V8
Phase: PHASE1 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Jun 15, 2026 18:55 UTC
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New scan could sharpen view of rectal cancer during treatment
Diagnosis OngoingThis early-phase trial tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to highlight rectal cancer cells. The goal is to see if this scan can show tumor extent and response more accurately than standard imaging before and after chemotherapy and radiation. About …
Matched conditions: STAGE IIIC RECTAL CANCER AJCC V8
Phase: EARLY_PHASE1 • Sponsor: City of Hope Medical Center • Aim: Diagnosis
Last updated Jun 15, 2026 18:56 UTC
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Cancer treatment costs under the microscope: new study tracks financial toll
Knowledge-focused OngoingThis study follows 565 people with stage I-III colon or rectal cancer to understand how treatment affects their finances and quality of life. Participants complete surveys about costs and financial well-being over 12 months. The goal is to help doctors better support patients fac…
Matched conditions: STAGE IIIC RECTAL CANCER AJCC V8
Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Knowledge-focused
Last updated Jun 16, 2026 12:51 UTC
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Blood tests may unlock secrets of rectal cancer
Knowledge-focused OngoingThis study looks at tiny cancer cells and DNA pieces floating in the blood of people with rectal cancer. Researchers want to see if these blood markers can tell us how the tumor responds to standard treatment. The study includes about 341 people with rectal cancer and healthy vol…
Matched conditions: STAGE IIIC RECTAL CANCER AJCC V8
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:05 UTC