PERSISTENT DEPRESSIVE DISORDER
Clinical trials for PERSISTENT DEPRESSIVE DISORDER explained in plain language.
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Can a Parkinson's drug boost brain function in depressed seniors?
Disease control CompletedThis study tested whether levodopa, a drug used for Parkinson's disease, can improve thinking speed, walking, and mood in older adults with depression. Researchers gave 79 participants either levodopa or a placebo for three weeks. The goal was to see if boosting dopamine could he…
Matched conditions: PERSISTENT DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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App aims to help mentally ill kick the habit
Disease control CompletedThis study tested whether a smartphone app designed for people with serious mental illness can help them quit smoking better than standard methods. Researchers enrolled 343 adults with conditions like bipolar disorder or schizophrenia who wanted to quit. Participants used either …
Matched conditions: PERSISTENT DEPRESSIVE DISORDER
Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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Zapping the brain to sharpen thinking in depressed seniors
Symptom relief CompletedThis study tested whether a gentle electrical current applied to the scalp (tDCS) could make computer-based brain training more effective for older adults with recurrent depression. Sixteen people aged 60 and older took part. The goal was to see if this combination improved memor…
Matched conditions: PERSISTENT DEPRESSIVE DISORDER
Phase: NA • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Scientists probe Brain's depression hub with magnetic pulses
Knowledge-focused CompletedThis study looks at how transcranial magnetic stimulation (TMS) affects a brain area called the subgenual cingulate, which is linked to depression. Researchers will give 54 adults with depression daily TMS sessions for 4-6 weeks, along with MRI scans, to see how this brain region…
Matched conditions: PERSISTENT DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jul 25, 2026 00:00 UTC
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Could insulin in the brain be linked to depression in teens?
Knowledge-focused CompletedThis study examined 24 adolescents (ages 14-18) with and without depression to see if their brains respond differently to insulin. Participants received insulin or a placebo nasal spray, and MRI scans measured brain activity and blood flow. The goal was to understand if brain ins…
Matched conditions: PERSISTENT DEPRESSIVE DISORDER
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC