PANCREAS ADENOCARCINOMA

This early-phase trial tests a new drug called ZM008, alone and with another drug (toripalimab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goal is to find a safe dose and check for side effects. About 100 adults with cancer…

This study is for people with pancreatic cancer that is borderline or locally advanced. It tests giving two standard chemotherapy combinations one after the other before surgery. The goal is to see if this sequence helps remove the tumor completely and safely. About 64 adults wil…

This early-stage trial tests the safety and best dose of a new drug called THE-0504 in 30 adults with advanced solid tumors, including lung, colon, stomach, breast, and pancreatic cancers. The main goal is to find the highest safe dose and check for side effects. Participants mus…

This study looks at how the genetic makeup of pancreatic cancer affects response to a chemotherapy called FOLFIRINOX given before surgery. About 45 adults with non-metastatic pancreatic cancer will receive the chemo, then have their tumors analyzed to see if genetic subtypes (lik…

This study is for people with pancreatic cancer that can be surgically removed. It tests whether giving chemotherapy and radiation before surgery helps surgeons remove all cancer cells more completely. About 30 adults will receive the drugs gemcitabine and nab-paclitaxel plus tar…

This study tests a new way of giving chemotherapy to people with pancreatic cancer that is on the edge of being removable. The goal is to shrink the tumor enough for successful surgery and to prevent the cancer from coming back. About 35 adults will receive two different chemo dr…

This trial tests whether giving three treatments together—two medicines and a surgical patch—can lower the risk of major complications after Whipple surgery for pancreatic cancer and other tumors. The study includes 400 high-risk patients with a small pancreatic duct. If successf…

This study tests whether adding surgery or radiation to standard chemotherapy helps people with metastatic upper GI cancer live longer without the disease getting worse. It includes 54 adults whose cancer has spread but whose blood shows no detectable tumor DNA after three months…

This study explores why many people with pancreatic cancer develop severe muscle wasting, called cachexia. Researchers will collect blood samples from 100 patients to look for genetic differences that may be linked to this condition. The goal is to better understand cachexia and …