NF1
Clinical trials for NF1 explained in plain language.
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New hope for kids with tough cancers: first pediatric trial of promising drug duo
Disease control Recruiting nowThis study is testing the safety of a new two-drug combination (avutometinib and defactinib) for children and young adults (ages 3-30) whose solid tumors have come back or stopped responding to standard treatments. The main goal is to find the highest dose that is safe and causes…
Matched conditions: NF1
Phase: PHASE1 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Apr 01, 2026 14:42 UTC
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Modified cold sore virus injected to fight disfiguring skin tumors
Disease control Recruiting nowThis early-stage study is testing whether a modified virus (IMLYGIC), already approved for some skin cancers, can be safely injected into the numerous, often painful or itchy, skin tumors caused by neurofibromatosis type 1 (NF1). Researchers will inject the virus directly into th…
Matched conditions: NF1
Phase: PHASE1 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC