MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Clinical trials for MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE explained in plain language.
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Pill vs. IV: Head-to-Head race to slow debilitating MS
Disease control OngoingThis large, late-stage study is testing whether a new daily oral medication, fenebrutinib, can slow the worsening of disability in adults with primary progressive multiple sclerosis (PPMS). It directly compares fenebrutinib against an existing intravenous (IV) treatment, ocrelizu…
Matched conditions: MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Phase: PHASE3 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Major trial tests drug to halt worsening disability in progressive MS
Disease control OngoingThis large, late-stage study is testing whether the drug ocrelizumab (Ocrevus®) can slow down the worsening of disability in adults with primary progressive multiple sclerosis (PPMS). Over 1,000 participants were randomly assigned to receive either the drug or a placebo (inactive…
Matched conditions: MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Phase: PHASE3 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Common supplement tested to protect brains in progressive MS
Disease control OngoingThis study is testing whether N-acetyl cysteine (NAC), an over-the-counter antioxidant supplement, can slow brain shrinkage in people with progressive multiple sclerosis. 98 participants aged 40-70 with progressive MS will receive either NAC or a placebo for 15 months. Researcher…
Matched conditions: MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Phase: PHASE2 • Sponsor: Emmanuelle Waubant, MD PhD • Aim: Disease control
Last updated Mar 17, 2026 12:55 UTC
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Scientists track the hidden toll of MS on the mind
Knowledge-focused OngoingThis study aims to understand how and why thinking and memory problems develop in people with primary progressive multiple sclerosis (PPMS). Researchers are following 66 patients for two years, using detailed brain scans and cognitive tests to see how brain changes relate to chan…
Matched conditions: MULTIPLE SCLEROSIS, PRIMARY PROGRESSIVE
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:17 UTC