MELANOMA STAGE IV
Clinical trials for MELANOMA STAGE IV explained in plain language.
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New vaccine combo shows promise in advanced skin cancer trial
Disease control OngoingThis study tests two experimental cancer vaccines, SCIB1 and iSCIB1+, when added to standard immunotherapy drugs (nivolumab with ipilimumab or pembrolizumab) for people with advanced melanoma that cannot be removed by surgery. The goal is to see if the vaccines are safe and can i…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Scancell Ltd • Aim: Disease control
Last updated May 17, 2026 01:00 UTC
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New hope for brain-spread cancers: dual immunotherapy injected into spinal fluid
Disease control OngoingThis early-phase study tests a new way to give immunotherapy drugs (nivolumab and ipilimumab) to people with lung cancer or melanoma that has spread to the lining of the brain and spinal cord (leptomeningeal metastases). The drugs are given both into the spinal fluid and through …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1 • Sponsor: University of Zurich • Aim: Disease control
Last updated May 14, 2026 12:03 UTC
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New combo therapy shows promise for advanced skin cancer
Disease control OngoingThis trial tests a new drug, EVX-01, combined with the standard immunotherapy pembrolizumab in 17 adults with advanced melanoma that cannot be removed by surgery. The goal is to see if adding EVX-01 improves tumor shrinkage compared to historical data with pembrolizumab alone. Pa…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Evaxion Biotech A/S • Aim: Disease control
Last updated May 13, 2026 16:03 UTC
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New drug ST101 tested in patients with advanced cancers
Disease control OngoingThis study tests a new drug called ST101 in people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to find a safe dose and see if the drug can shrink tumors. About 125 adults with cancers like glioblastoma, melanoma, breast, or prostate ca…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1, PHASE2 • Sponsor: Sapience Therapeutics • Aim: Disease control
Last updated May 13, 2026 15:58 UTC
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New combo aims to unleash immune system on tough melanoma
Disease control OngoingThis early-stage study tests a new drug, SX-682, in people with advanced melanoma that has spread. The drug is designed to block cancer from hiding from the immune system. Participants first take SX-682 alone, then add the immunotherapy pembrolizumab for up to two years. The goal…
Matched conditions: MELANOMA STAGE IV
Phase: PHASE1 • Sponsor: Syntrix Biosystems, Inc. • Aim: Disease control
Last updated May 08, 2026 12:02 UTC
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New combo therapy aims to shrink melanoma before surgery
Disease control OngoingThis study tests whether giving immunotherapy drugs before surgery can shrink advanced melanoma (stage III or IV) that can be removed. About 48 adults will receive either one drug (dostarlimab) or two drugs (dostarlimab plus cobolimab) before their operation. The main goal is to …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Diwakar Davar • Aim: Disease control
Last updated May 06, 2026 16:13 UTC
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New hope for skin cancer patients suffering from severe gut side effects of immunotherapy
Symptom relief OngoingThis study looks at whether infliximab can treat colitis (inflammation of the colon) caused by immunotherapy drugs in people with advanced skin cancer. About 42 participants will receive either infliximab or steroids to see which works better at stopping symptoms without needing …
Matched conditions: MELANOMA STAGE IV
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated May 12, 2026 13:42 UTC
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Melanoma study aims to uncover hidden toll of immunotherapy
Knowledge-focused OngoingThis study looks at side effects and quality of life in people with melanoma who are getting immunotherapy after surgery. Researchers will track symptoms, blood markers, and how patients feel over two years. The goal is to learn more about why some people have side effects and ho…
Matched conditions: MELANOMA STAGE IV
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 17, 2026 00:47 UTC