LOCALLY ADVANCED BREAST CARCINOMA
Clinical trials for LOCALLY ADVANCED BREAST CARCINOMA explained in plain language.
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New drug duo targets hard-to-treat HER2 cancers in early trial
Disease control Recruiting nowThis early-phase trial tests the safety and best dose of two drugs given together for people with advanced breast cancer or other solid tumors that have a protein called HER2. The drugs are pidnarulex (which stops cancer cells from repairing themselves) and trastuzumab deruxtecan…
Matched conditions: LOCALLY ADVANCED BREAST CARCINOMA
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 13, 2026 15:58 UTC
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New hope for advanced cancers with DNA repair flaws: PARP inhibitor trial opens
Disease control Recruiting nowThis study tests the drug talazoparib in adults with advanced solid tumors (like breast, prostate, ovarian, pancreatic, or stomach cancer) that have certain gene changes affecting DNA repair. The drug blocks a protein called PARP, which cancer cells need to fix their DNA, potenti…
Matched conditions: LOCALLY ADVANCED BREAST CARCINOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 12, 2026 13:43 UTC
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New ultrasound test may predict chemo success early in breast cancer
Diagnosis Recruiting nowThis study tests a new ultrasound technique that uses a contrast dye to measure pressure inside breast tumors. The goal is to see if it can predict how well chemotherapy is working early in treatment. 200 women with locally advanced breast cancer will be scanned before and during…
Matched conditions: LOCALLY ADVANCED BREAST CARCINOMA
Phase: PHASE2, PHASE3 • Sponsor: Kibo Nam • Aim: Diagnosis
Last updated May 01, 2026 15:58 UTC
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New surgery before lymph node removal may prevent painful arm swelling
Prevention Recruiting nowThis study tests if a surgery called lymphovenous bypass, done before lymph node removal, can prevent lymphedema (arm swelling) in people with breast cancer or melanoma. About 252 participants will be followed to see if the bypass reduces the chance of swelling compared to standa…
Matched conditions: LOCALLY ADVANCED BREAST CARCINOMA
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Prevention
Last updated May 17, 2026 08:52 UTC
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New ultrasound marker aims to make breast cancer surgery safer and more precise
Knowledge-focused Recruiting nowThis early-stage study tests a new type of marker that shows up better on ultrasound for people with breast cancer that has spread to lymph nodes. The marker is placed in the affected node to help doctors find and remove it during surgery. The goal is to see if this marker is saf…
Matched conditions: LOCALLY ADVANCED BREAST CARCINOMA
Phase: PHASE1 • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated May 13, 2026 15:58 UTC