IRRITABLE MOOD

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Trials to join now! 2 Completed 1

Brain study reveals why menopause hormones trigger irritability in some women

Knowledge-focused Completed

This study looked at why some women in early menopause become irritable when their estrogen levels change. Forty healthy women aged 45-59 with moderate to severe irritability took either estrogen or a placebo for three weeks. Researchers measured their brain activity and mood to …

Matched conditions: IRRITABLE MOOD

Phase: PHASE4 • Sponsor: University of North Carolina, Chapel Hill • Aim: Knowledge-focused

Last updated May 14, 2026 12:03 UTC

IRRITABLE MOOD

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Brain study reveals why menopause hormones trigger irritability in some women