HYDROCEPHALUS

This study looks at how safe and well a new adjustable valve system works for people with hydrocephalus, a condition where fluid builds up in the brain. About 126 patients will receive the valve to help drain excess fluid. The main goals are to see if the valve causes serious sid…

This program gives children with brain disorders like cerebral palsy or stroke access to umbilical cord blood infusions. The treatment uses donated cord blood cells to help repair brain damage. Kids up to age 26 with normal immune function may qualify. The goal is to improve symp…

This study is testing a small, wireless device that sticks to the skin over a shunt tube to see if fluid is flowing inside. It uses gentle warmth to measure temperature changes without breaking the skin. The trial includes 55 children and adults with hydrocephalus who already hav…

This study tests a new MRI technique to measure how cerebrospinal fluid flows in the brain. Researchers will compare 50 healthy volunteers and patients with conditions like Alzheimer's disease or normal pressure hydrocephalus. The goal is to improve diagnosis and understanding of…

This study is testing a new way to detect motor delays in infants using a special play mat with sensors and a smart toy. Researchers will watch how babies move and interact with the toy, then use AI to spot early signs of disability. The goal is to create an easy, objective tool …

This study tests whether using ultrasound to guide placement of a brain drain (external ventricular drain) in adults with hydrocephalus can improve accuracy and reduce the number of needle passes needed. Ten participants will have the drain placed with the SOLOPASS® ultrasound sy…

This study follows 140 people with early signs of normal pressure hydrocephalus (NPH) to see if brain scans and fluid tests can predict who will get worse and need shunt surgery. Participants include those with mild symptoms, those with clear NPH, and healthy volunteers. The goal…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study tests a new wireless sensor called FlowSense, which is placed on the skin like a bandage to measure fluid flow in hydrocephalus patients with external drains. The goal is to see if it can accurately track drainage and pressure without needing X-rays or hospital equipme…

This study tests a non-invasive light-based device to measure blood flow and oxygen use in the brains of premature infants who have bleeding or fluid buildup. Researchers will compare these measurements in affected babies, those with other types of fluid buildup, and healthy newb…

This study is looking at 160 people who had a ruptured brain aneurysm and need a temporary drain. Researchers will measure glucose in their spinal fluid and blood daily for up to 14 days. The goal is to see if higher glucose levels are linked to needing a permanent shunt later. P…

This lab study uses leftover spinal fluid from 10 patients with normal pressure hydrocephalus to see if common numbing medicines form crystals. Researchers mix different drugs and watch for crystals over 60 minutes. The goal is to understand risks, not to treat patients directly.

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study looks at whether giving antibiotics for just 24 hours around the time of placing a special antibiotic-coated brain drain works as well as giving them for the whole time the drain is in place. The goal is to find the best way to prevent serious brain infections in peopl…

This study watches 148 adults with acute brain injury who have a drain in their head. Researchers will check fluid from the brain to see if changes in a substance called lactate can signal an infection early. The goal is to learn more, not to test a new treatment.