HEPATIC INSUFFICIENCY
Clinical trials for HEPATIC INSUFFICIENCY explained in plain language.
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Liver study tests drug safety for future patients
Knowledge-focused CompletedThis study aimed to understand how a breast cancer drug, imlunestrant, is processed by the body in people with different levels of liver function. It compared the drug's levels in the blood of women with impaired livers to those with healthy livers. The goal was to gather safety …
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Eli Lilly and Company • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:11 UTC
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Liver's role in cancer drug safety tested
Knowledge-focused CompletedThis study aims to understand how liver disease changes the way the body processes an experimental cancer drug called sevabertinib. Researchers compared about 20 people—half with moderate liver problems and half with healthy livers—after each took a single dose. By measuring drug…
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Bayer • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:32 UTC
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First step: testing new drug in people with liver problems
Knowledge-focused CompletedThis early study aimed to understand how a new drug, olomorasib, is processed by people with different levels of liver impairment compared to healthy people. It involved 46 participants who received a single dose, with a focus on measuring drug levels in the blood and checking fo…
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Eli Lilly and Company • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:28 UTC
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Liver's drug processing power under the microscope
Knowledge-focused CompletedThis study tested how a medicine called BI 1015550 behaves in people with and without liver problems. Researchers compared 28 adults with mild or moderate liver impairment to matched healthy participants, giving everyone a single dose. They measured drug levels in the blood over …
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Boehringer Ingelheim • Aim: Knowledge-focused
Last updated Mar 25, 2026 14:08 UTC
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Liver study tests drug safety for vulnerable patients
Knowledge-focused CompletedThis study aimed to understand how a damaged liver processes an experimental drug called bomedemstat (MK-3543). Nine participants, some with mild or moderate liver problems and some healthy, took a single dose. Researchers tracked how much of the drug stayed in their blood over t…
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Merck Sharp & Dohme LLC • Aim: Knowledge-focused
Last updated Mar 23, 2026 15:18 UTC