HEPATIC INSUFFICIENCY
Clinical trials for HEPATIC INSUFFICIENCY explained in plain language.
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Liver function may change how brain drug works
Knowledge-focused CompletedThis study looked at how the experimental brain medicine iclepertin is processed in people with and without liver problems. About 29 adults took a single dose of the drug, and researchers measured its levels in the blood. The goal was to see if liver impairment changes how the bo…
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Boehringer Ingelheim • Aim: Knowledge-focused
Last updated May 17, 2026 05:37 UTC
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Liver health may change how drug olomorasib works in the body
Knowledge-focused CompletedThis study looked at how the drug olomorasib enters the blood and how long it takes the body to clear it in people with mild, moderate, or severe liver problems compared to those with healthy livers. A total of 46 adults took a single dose and were monitored for safety and drug l…
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Eli Lilly and Company • Aim: Knowledge-focused
Last updated May 17, 2026 05:32 UTC
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Liver study reveals how body handles new drug
Knowledge-focused CompletedThis study looked at how the drug bomedemstat (MK-3543) moves through the body in people with mild or moderate liver problems compared to healthy volunteers. Nine participants received a single dose, and researchers measured drug levels in the blood. The goal was to understand if…
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Merck Sharp & Dohme LLC • Aim: Knowledge-focused
Last updated May 17, 2026 05:29 UTC
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Liver health may change how cancer drug works
Knowledge-focused CompletedThis study looked at how moderate liver problems affect the way the body handles a new cancer medicine called sevabertinib. About 20 people (10 with liver impairment and 10 healthy) took a single dose and had their blood levels measured. The goal is to help doctors decide the rig…
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Bayer • Aim: Knowledge-focused
Last updated May 17, 2026 05:29 UTC
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Liver scan may predict deadly failure after major surgery
Knowledge-focused CompletedThis study looked at whether a special liver scan (hepatobiliary scintigraphy) can predict the risk of liver failure after removing a large part of the liver. 326 adults with non-cirrhotic livers who needed major liver surgery took part. The goal was to see if the scan gives bett…
Matched conditions: HEPATIC INSUFFICIENCY
Phase: NA • Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated May 15, 2026 11:56 UTC
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Liver function and drug processing: a closer look
Knowledge-focused CompletedThis study looked at how the medicine BI 1015550 is absorbed and processed in the blood of people with mild or moderate liver problems compared to those with healthy livers. 28 adults took a single dose and had blood samples taken over several days. The goal was to see if liver i…
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Boehringer Ingelheim • Aim: Knowledge-focused
Last updated May 08, 2026 12:02 UTC
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Liver function and drug levels: new study on imlunestrant
Knowledge-focused CompletedThis study looked at how imlunestrant, a drug being tested for certain cancers, is processed by the body in women with and without liver issues. 27 women took part to see how liver function affects drug levels and side effects. The results help doctors understand safe dosing for …
Matched conditions: HEPATIC INSUFFICIENCY
Phase: PHASE1 • Sponsor: Eli Lilly and Company • Aim: Knowledge-focused
Last updated May 07, 2026 18:43 UTC