GENITOURINARY CANCER

This phase 2 trial tests whether a patient's own white blood cells, genetically modified in a lab to recognize and attack their specific tumor mutations, can shrink metastatic cancers. Participants include people with several advanced solid tumors or multiple myeloma who have exh…

This early-phase study tests two drugs, bintrafusp alfa and PDS01ADC, alone or with targeted radiation, in 100 adults with metastatic bladder, kidney, or other non-prostate genitourinary cancers. The goal is to see if the combination can help the immune system fight cancer better…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This phase 2 trial tests whether riluzole, a drug already approved for ALS, can prevent the cognitive problems (often called 'chemo brain') that many cancer patients face during chemotherapy. The study will enroll 24 adults with various cancers who are about to start chemotherapy…

This study tests a program for older adults (65+) with cancer and mild memory issues, along with their spouse or caregiver. Over six video sessions, the pair learns strategies to manage challenges. The goal is to see if the program reduces distress and improves quality of life. A…

This study follows 1,100 adults with rare urinary tract cancers, such as unusual bladder, kidney, testicular, or penile cancers. Researchers will collect medical records, blood and tumor samples, and imaging over many years to understand how these cancers grow and respond to trea…

This study aims to collect and analyze tumor samples from 10,000 adults with advanced solid cancers (like breast, lung, or colon cancer) to create a province-wide gene database. The goal is to help doctors identify which targeted drugs or clinical trials might work best for each …

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at a cure. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA left behind. The goal is to find any remaining cancer as early as p…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning earlier than standard scans. About 100 people with different solid tumors will give blood samples after treatment. The goal is to see if early detection can lead to better treatm…

This study follows 500 people with genitourinary cancers (like prostate, bladder, or kidney cancer) to see how well recently approved drugs work in everyday Spanish hospitals. Researchers will collect data from patients already taking these medications, without changing their tre…

This study looks at whether adding an oncology research navigator (ORN) to standard cancer navigation helps patients with cancer. About 686 adults with new cancer appointments will take part. Some will get the usual navigation, while others also get an ORN who helps them find sup…

This study looks at how many opioid pain pills patients actually take after surgery for bladder, kidney, or prostate cancer. About 684 adults will report their opioid use 30 days after leaving the hospital. The study also tests whether a simple pamphlet helps people safely dispos…