DOWN SYNDROME (TRISOMY 21)
Clinical trials for DOWN SYNDROME (TRISOMY 21) explained in plain language.
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New drug trial targets Alzheimer's risk in down syndrome
Disease control Not yet recruitingThis study is testing whether the drug donanemab can reduce the buildup of a harmful protein called amyloid in the brains of adults with Down syndrome. About 60 participants, aged 35-50, will receive monthly infusions of either donanemab or a placebo for one year, followed by an …
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Phase: PHASE4 • Sponsor: Michael Rafii, MD, PhD • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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New pill aims to boost independence for people with down syndrome
Symptom relief Not yet recruitingThis study is testing whether a daily pill called AEF0217 can help improve daily living skills, thinking, and quality of life for older teens and adults with Down syndrome. About 188 participants will take either the drug or a placebo (a dummy pill) for 24 weeks. Researchers will…
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Phase: PHASE2 • Sponsor: Aelis Farma • Aim: Symptom relief
Last updated Mar 23, 2026 15:17 UTC
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Brain scans probe why some trust too much, others too little
Knowledge-focused Not yet recruitingThis study aims to understand how people with intellectual disabilities, specifically Down syndrome and Fragile X syndrome, decide who to trust. Researchers will use computer tasks, eye-tracking, and brain scans (MRI) to compare how 112 participants from these groups and typical …
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Apr 02, 2026 00:56 UTC
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Researchers seek feedback on experimental down syndrome drug
Knowledge-focused Not yet recruitingThis study asks caregivers and participants from a previous Down syndrome drug trial to share their experiences. The goal is to gather feedback on what effects, if any, they perceived during the trial. Researchers will use a single online questionnaire to collect this information…
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Sponsor: Aelis Farma • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:38 UTC
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Could a Baby's sucking pattern reveal a hidden sleep danger?
Knowledge-focused Not yet recruitingThis study aims to understand the link between how infants with Down syndrome suck on a pacifier and the severity of their sleep apnea. Researchers will measure sucking patterns and sleep breathing in 30 six-month-old infants to see if a simple sucking test could become an easier…
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Mar 24, 2026 12:03 UTC