DOWN SYNDROME (TRISOMY 21)
Clinical trials for DOWN SYNDROME (TRISOMY 21) explained in plain language.
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Could a drug clear Alzheimer's plaques in people with down syndrome?
Disease control Not yet recruitingThis study tests whether donanemab, given as an IV infusion every 4 weeks, can safely lower amyloid plaques in the brains of 60 adults aged 35–50 with Down syndrome. Participants receive either donanemab or a placebo for 12 months, followed by a 12-month extension where everyone …
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Phase: PHASE4 • Sponsor: Michael Rafii, MD, PhD • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Could a pacifier help babies with down syndrome breathe better at night?
Prevention Not yet recruitingThis study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measur…
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Prevention
Last updated Jun 27, 2026 14:00 UTC
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Scientists to unravel trust in intellectual disability
Knowledge-focused Not yet recruitingThis study looks at how people with Down syndrome and Fragile X syndrome decide who to trust. Researchers will use eye-tracking and behavioral tasks to measure how participants read faces, behaviors, and detect deception. The goal is to understand the brain mechanisms behind trus…
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC