BRCA MUTATION
Clinical trials for BRCA MUTATION explained in plain language.
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New drug combo targets tough cancers in early trial
Disease control Recruiting nowThis early-phase study tests a combination of two oral drugs, olaparib and ASTX727, in adults with advanced solid tumors that have mutations in genes like BRCA1, BRCA2, PALB2, ATM, or CHEK2. The main goals are to find the safest dose and to check for side effects. About 18 partic…
Matched conditions: BRCA MUTATION
Phase: PHASE1 • Sponsor: Varun Monga, MBBS • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New daily pill hopes to control advanced cancers
Disease control Recruiting nowThis early-stage trial is testing a new daily oral medication called ETX-19477 in about 120 adults with advanced solid tumors, including breast, ovarian, prostate, and other cancers. The drug blocks a protein called PARG to interfere with cancer cells' ability to repair themselve…
Matched conditions: BRCA MUTATION
Phase: PHASE1, PHASE2 • Sponsor: 858 Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Can an ultrasound spot cancer genes? new study aims to find out
Diagnosis Recruiting nowThis study tests whether ultrasound images of healthy ovaries can predict if a woman carries a harmful BRCA gene mutation, which raises the risk of breast and ovarian cancers. Researchers will develop a computer model using thousands of images from women with known BRCA status. I…
Matched conditions: BRCA MUTATION
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Diagnosis
Last updated Jun 27, 2026 12:23 UTC
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New scan may improve cancer detection for men with inherited risk
Diagnosis Recruiting nowThis study compares a new PET-CT scan (FCH-PET-CT) to standard imaging (bone scan and MRI/CT) to see which better finds cancer that has spread outside the pelvis in men with prostate cancer and specific DNA repair gene mutations. About 50 men with these mutations will be enrolled…
Matched conditions: BRCA MUTATION
Sponsor: Institute of Cancer Research, United Kingdom • Aim: Diagnosis
Last updated Jun 27, 2026 08:04 UTC