ADVANCED MALIGNANT NEOPLASM

This early-stage trial aims to find safe doses and understand side effects of several drug combinations for patients with advanced cancers that haven't responded to standard treatments. The study involves 155 participants with various advanced or metastatic cancers and some rare …

This study is testing an oral medication called talazoparib for people with advanced cancers that have spread, returned, or stopped responding to standard treatments. It is specifically for patients whose cancers have certain genetic changes in the BRCA pathway (like BRCA1, BRCA2…

This study is testing an experimental drug called vimseltinib in adults with advanced solid tumors or a rare joint tumor called tenosynovial giant cell tumor (TGCT). The first phase aims to find the safest and most effective dose. The second phase will focus on TGCT patients to s…

This early-stage study is testing the safety and best dose of combining standard chemotherapy drugs with a portable device that uses electrical fields to try to stop tumor growth. It is for patients whose cancer has spread to the liver and has not responded to other treatments. T…

This study aims to see if a common stimulant medication (methylphenidate) combined with a guided exercise program can reduce severe, cancer-related fatigue. It involves 212 patients with advanced cancer who are receiving a specific type of immunotherapy (anti-PD1) and are struggl…

This study is testing whether combining physical activity with a short course of the steroid dexamethasone can reduce severe, persistent fatigue in people with advanced cancer. It will compare a high dose and a low dose of the steroid, both paired with a 4-week exercise program. …

This study is testing different medication strategies to quickly calm severe, distressing agitation (delirium) in hospitalized patients with advanced cancer. It involves 70 patients whose initial low-dose medication hasn't worked. Researchers are comparing three approaches: incre…

This study is testing a procedure called cordotomy to see if it can reduce severe pain in people with advanced cancer when other pain treatments haven't worked. Doctors use a needle guided by a CT scan to interrupt pain signals in the spinal cord. The goal is to see if this provi…

This study aims to understand the preferences of advanced cancer patients and their caregivers regarding where they wait during outpatient palliative care visits. Researchers want to know if patients and caregivers prefer to go directly to an exam room or wait in a common waiting…

This study is testing two different information sheets to see which one helps patients with advanced cancer and their caregivers communicate better with their doctors. It involves 207 patients, their caregivers, and their palliative care physicians. The goal is to see if a specif…

This study aims to understand how common and severe financial distress is for people with advanced cancer. Researchers are asking 141 patients to complete short surveys about their financial situation, symptoms, and quality of life. The goal is to learn how the high cost of cance…