ADVANCED MALIGNANT NEOPLASM

This study tests a new drug called ziftomenib for people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The trial includes about 263 participants and aims to find the safest dose and see if the drug can control the disease. It also looks at ho…

This early-phase trial tests the safety and best doses of two drugs (bevacizumab and temsirolimus) given alone or with other medicines (valproic acid or cetuximab) in people with advanced cancer or certain non-cancerous diseases that are hard to treat. The goal is to find the hig…

This study tests an experimental drug called vimseltinib in people with advanced solid tumors or a rare joint tumor called tenosynovial giant cell tumor (TGCT). The goal is to find the safest dose and see if the drug shrinks tumors or improves joint movement. About 120 adults wil…

This early-phase study tests a portable device that creates electric fields to disrupt cancer cell growth, combined with chemotherapy and a targeted drug, in people whose cancer has spread to the liver and stopped responding to standard treatments. The main goal is to find the sa…

This study tests a drug called talazoparib in people with advanced cancers that have not responded to standard treatments. The drug works by blocking an enzyme that helps cancer cells survive, especially in tumors with changes in the BRCA genes or related DNA repair genes. The go…

This study tests whether adding a short course of the steroid dexamethasone to a physical activity program can reduce severe fatigue in people with advanced cancer. About 90 participants will be randomly assigned to receive either a high or low dose of dexamethasone along with ex…

This study looks at whether a medication called methylphenidate (often used for ADHD) combined with physical activity can reduce severe tiredness in people with advanced cancer who are on immunotherapy. About 212 participants will be randomly assigned to receive either the drug o…

This study looks at whether haloperidol, given alone or with chlorpromazine, can safely reduce severe agitation and confusion (delirium) in people with advanced cancer who are in a palliative care unit. About 70 participants will receive the drugs and be monitored for 24 hours. T…

This study tests a procedure called cordotomy to reduce severe pain in people with advanced cancer. A needle is guided by CT scans to the spinal cord to block pain signals. The study enrolled 27 adults with uncontrolled pain on one side of the body below the shoulder. The goal is…

This study looks at whether cancer patients and their caregivers prefer to wait in an exam room instead of a waiting room when visiting a supportive care clinic. About 406 participants will share their opinions through a questionnaire. The goal is to understand what makes the cli…

This study looks at whether giving advanced cancer patients and their caregivers a special information sheet helps them communicate better with their doctors. About 207 patients will receive either a question prompt sheet or a general information sheet before their first visit wi…

This study looks at how serious money problems are for people with advanced cancer. Cancer care can be very expensive, and the stress from debt and high costs may make physical symptoms and quality of life worse. About 141 patients will fill out a short survey to measure their fi…