Xeroderma pigmentosum
MONDO:0019600Xeroderma pigmentosum (XP) is a rare genodermatosis characterized by extreme sensitivity to ultraviolet (UV)-induced changes in the skin and eyes, and multiple skin cancers. It is subdivided into 8 complementation groups, according to the affected gene: classical XP (XPA to XPG) and XP variant (XPV).
Also known as: Kaposi dermatosis, Kaposi disease, XP, angioma pigmentosum atrophicum, atrophoderma pigmentosum, melanosis lenticularis progressiva, pigmented epitheliomatosis, xeroderma of Kaposi
9 clinical trials for this condition and its sub-types.
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Broader categories
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Gene therapy offers hope for babies with 'Bubble Boy' disease
⭐️ CURE ⭐️ Recruiting nowThis study tests a new gene therapy for children with a severe immune disorder called Artemis-SCID, where the body cannot fight infections. Doctors take the child's own blood stem cells, fix the faulty gene in a lab, and put the corrected cells back. The goal is to rebuild a work…
Phase: PHASE1, PHASE2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: ⭐️ CURE ⭐️
Last updated Jun 27, 2026 12:00 UTC
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New drug combo targets Hard-to-Treat cancers in early trial
Disease control Recruiting nowThis study tests a new drug called AZD4956, alone or with other cancer drugs, in people with advanced or spreading solid tumors that have a specific DNA repair defect (HRR deficiency). The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. …
Phase: PHASE1, PHASE2 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Aug 13, 2026 00:00 UTC
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Scientists track rare DNA repair diseases to learn how they progress
Knowledge-focused Recruiting nowThis study is for people with rare DNA repair disorders like Cockayne syndrome, xeroderma pigmentosum, or trichothiodystrophy. Researchers will watch how symptoms like movement and balance change over time. No treatments are given—the goal is to better understand these conditions…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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5G Radiation's hidden impact on skin revealed in new trial
Knowledge-focused Recruiting nowThis study looks at how high-frequency 5G waves (27.5 GHz) affect the skin. Researchers will expose healthy volunteers and people with certain skin conditions to these waves and analyze skin cell changes using advanced techniques. The goal is to understand any biological effects,…
Phase: NA • Sponsor: Prof. Olivier Gaide, MD-PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC