Wolfram syndrome
MONDO:0018105Wolfram syndrome (WS) also known as DIDMOAD, is a neurodegenerative disorder characterized by type I diabetes mellitus (DM), diabetes insipidus (DI), sensorineural deafness (D), bilateral optical atrophy (OA) and neurological signs. Other related problems are urinary tract atony, ataxia, peripheral neuropathy, psychiatric disorders and/or seizures. 2 types of WS may be distinguished: type 1 and type 2 (WS1 and WS2).
Also known as: DIDMOAD, DIDMOAD syndrome, Wolfram syndrome, diabetes insipidus, diabetes mellitus, optic atrophy, and deafness syndrome, diabetes insipidus-diabetes mellitus-optic atrophy-deafness syndrome, diabetes mellitus and insipidus with optic atrophy and deafness
7 clinical trials for this condition and its sub-types.
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Scientists turn skin and blood into insulin factories to fight diabetes
Knowledge-focused Recruiting nowThis study takes a small sample of skin, blood, or urine from people with diabetes and healthy volunteers. Scientists will turn those cells into stem cells and then into insulin-producing cells in the lab. The goal is to learn more about diabetes and pave the way for future cell-…
Phase: NA • Sponsor: Ospedale San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Global registry launches to unlock secrets of rare wolfram syndrome
Knowledge-focused Recruiting nowThis study is building a worldwide registry for people with Wolfram syndrome, a rare genetic disorder causing diabetes, vision loss, and hearing problems. Researchers will track how the disease progresses over time and analyze participants' genetic information. The goal is to bet…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC