Wolfram syndrome
MONDO:0018105Wolfram syndrome (WS) also known as DIDMOAD, is a neurodegenerative disorder characterized by type I diabetes mellitus (DM), diabetes insipidus (DI), sensorineural deafness (D), bilateral optical atrophy (OA) and neurological signs. Other related problems are urinary tract atony, ataxia, peripheral neuropathy, psychiatric disorders and/or seizures. 2 types of WS may be distinguished: type 1 and type 2 (WS1 and WS2).
Also known as: DIDMOAD, DIDMOAD syndrome, Wolfram syndrome, diabetes insipidus, diabetes mellitus, optic atrophy, and deafness syndrome, diabetes insipidus-diabetes mellitus-optic atrophy-deafness syndrome, diabetes mellitus and insipidus with optic atrophy and deafness
7 clinical trials for this condition and its sub-types.
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Broader categories
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Are these two eye diseases actually the same? new study aims to find out
Knowledge-focused Not yet recruitingThis study will look back at medical records of 45 people with either Wolfram syndrome or a related eye condition caused by changes in the WFS1 gene. Researchers want to see if these two conditions are truly different by comparing vision loss over time and other health problems. …
Sponsor: Hôpital Necker-Enfants Malades • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Rare disease mystery: what causes fecal incontinence in wolfram syndrome?
Knowledge-focused Not yet recruitingThis study looks at medical records of 20 people with Wolfram syndrome to find out why they have trouble controlling their bowels. Researchers want to identify risk factors and better understand the cause. No new treatments are being tested.
Sponsor: Hôpital Necker-Enfants Malades • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC