Tongue disorder

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This study tests whether a mixed reality system, similar to video game technology, can help surgeons remove oral cancer and rebuild the area more accurately. Thirty people with oral cancer will be split into three groups: one using mixed reality, one using a virtual surgical guid…

This phase II trial tests whether surgically cutting the lingual nerve (which controls tongue sensation) can make chemoimmunotherapy work better for people with advanced tongue cancer. 69 adults with stage T3/T4 tongue cancer will receive the nerve cut along with two cycles of ti…

This trial tests whether a two-week tongue-strengthening exercise, done with a non-invasive device, can improve speech fluency in people with tongue-tie or slurred speech. The exercise relies on muscle resistance training, not medication or electronics. Researchers will measure c…

This study follows about 146 mother-infant pairs to see if tongue-tie (ankyloglossia) affects how well breastfeeding goes. Newborns are checked for tongue-tie within their first 72 hours using the TABBY tool, and breastfeeding effectiveness is measured with the LATCH scale. The r…