Telomere syndrome
MONDO:0100137Accelerated aging syndromes often caused by inheritable gene mutations resulting in decreased telomere lengths.
Also known as: STS, short telomere syndrome
92 clinical trials for this condition and its sub-types, 9 tagged with Telomere syndrome itself.
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Sub-types of Telomere syndrome
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Cirrhosis, familial 4 trials · 79 incl. sub-types
3 sub-types
- Primary biliary cholangitis 74 trials Sub-types →
- Isolated congenital hepatic fibrosis 2 trials
- Cirrhosis, familial, with antigenemia 0 trials
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4 sub-types
- Immunodeficiency-centromeric instability-facial anomalies syndrome 1 0 trials
- Immunodeficiency-centromeric instability-facial anomalies syndrome 2 0 trials
- Immunodeficiency-centromeric instability-facial anomalies syndrome 3 0 trials
- Immunodeficiency-centromeric instability-facial anomalies syndrome 4 0 trials
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9 sub-types
- Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 7 0 trials
- Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8 0 trials
- Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 0 trials
- Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 1 0 trials
- Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 2 0 trials
- Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 3 0 trials
- Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 4 0 trials
- Pulmonary fibrosis and/or bone marrow failure, telomere-related, 5 0 trials
- Pulmonary fibrosis and/or bone marrow failure, telomere-related, 6 0 trials
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2 sub-types
- ACD-related long telomere syndrome 0 trials
- ACD-related short telomere syndrome 0 trials Sub-types →
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Coats plus syndrome 0 trials
Most studied deeper sub-types
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Could a simple sugar pill fix faulty telomeres? early trial launches
Disease control Recruiting nowThis early-stage trial is testing whether a combination of two natural substances, deoxycytidine and deoxythymidine, is safe for people with telomere biology disorders. These rare genetic conditions cause premature aging, bone marrow failure, and lung scarring. Up to 36 participa…
Phase 1 • Sponsor: Suneet Agarwal • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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New stem cell transplant could reduce immune suppression in bone marrow failure patients
Disease control Recruiting nowThis phase 2 trial tests a special stem cell transplant for people with inherited bone marrow failure disorders like Fanconi anemia. The transplant uses a technique to remove certain immune cells, aiming to reduce the need for long-term immune-suppressing drugs and lower infectio…
Phase 2 • Sponsor: Masonic Cancer Center, University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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New transplant approach aims to fix broken immune systems
Disease control Recruiting nowThis phase 2 trial is testing a stem cell transplant using a milder chemotherapy regimen to treat people with severe immune deficiencies and inherited bone marrow failure. The goal is to see if donor cells can safely take over and rebuild a healthy immune system. Up to 27 partici…
Phase 2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Can a common plant compound help rare telomere disease?
Symptom relief Recruiting nowThis pilot study tests whether quercetin, a natural antioxidant found in many plants, is safe for people with Dyskeratosis congenita or telomere biology disorders. Twelve participants will take quercetin for 24 weeks while researchers monitor side effects and how well people stic…
Phase 1 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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20-Year study to track rare bone marrow diseases
Knowledge-focused Recruiting nowThis study follows people with acquired or inherited bone marrow failure for up to 20 years to learn how the diseases and treatments affect the body over time. Participants, aged 2 and older, will have regular check-ups and tests every 1 to 3 years. The goal is to better understa…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC