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T-B- severe combined immunodeficiency

MONDO:0017855

T-B- severe combined immunodeficiency (SCID) is a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T and B lymphocytes, resulting in recurrent early-onset severe respiratory viral, bacterial or fungal infections, diarrhea and failure to thrive. Hypersensitivity to ionizing radiation is a characteristic feature of some of its sub-types.

Also known as: T-B- SCID

16 clinical trials for this condition and its sub-types.

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Sub-types

Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency (6) Omenn syndrome (4) Severe combined immunodeficiency due to DCLRE1C deficiency (3) Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive (2) DNA ligase IV deficiency (1) Reticular dysgenesis (1) Cernunnos-XLF deficiency (0) Combined immunodeficiency due to partial RAG1 deficiency (0) Combined immunodeficiency with skin granulomas (0) Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia (0) Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia (0) Immunoerythromyeloid hypoplasia (0) Neutrophil immunodeficiency syndrome (0) Reticular dysgenesis-like severe combined immunodeficiency (0) Severe combined immunodeficiency due to DNA-PKcs deficiency (0) Severe combined immunodeficiency due to LCK deficiency (0) Short-limb skeletal dysplasia with severe combined immunodeficiency (0)

Broader categories

Disease (717) Hereditary disease (188) Immune system disorder (150) Immunodeficiency disease (55) Severe combined immunodeficiency (23) Human disease (15) Combined immunodeficiency (3) Disease of genetic or genomic mechanism (2) Disease by body system or component (0) Disease by etiologic mechanism (0)
Trials to join now! 4 Not yet recruiting 1 Not yet finished but already full! 8 Completed 2 Terminated 1
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